https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/106 2026-04-04T09:43:13Z 2026-04-04T09:43:13Z Kim, J. H. Chung, J. H. Kim, Y. Y. Kim, W. Y. Lee, J. B. Woo, S. U. https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64068 2023-12-14T03:31:04Z 202303-01-01T00:00:00Z

Title: Breast cancer patients aged 70 and over: clinical characteristics, treatment, and prognosis Authors: Kim, J. H.; Chung, J. H.; Kim, Y. Y.; Kim, W. Y.; Lee, J. B.; Woo, S. U. Abstract: Goals: Breast cancer incidence in the elderly is rising with overall increased life-expectancy. Evidence-based treatment guidelines for this subgroup, however, is lacking as women over the age of 70 have been largely excluded from clinical trials. Older patients are more prone to under-treatment due to their comorbidities, frailty, and consensus that breast cancer in older women are associated with more favorable prognostic factors. The aim of this study was to verify tumor characteristics in patients 70 years and older, review treatments they received, and compare recurrence and breast-cancer specific survival to those of younger subgroups to validate the appropriateness of current management in older breast cancer patients. Methods: From January 2009 to December 2019, newly diagnosed breast cancer patients of 50 years old or over who underwent curative surgery in Korea University Guro Hospital were enrolled in this study. Patients were categorized into 2 groups: those aged 70 years and over, and those between 50 and 69 years old. Their clinical characteristics including subtypes, histologic grade, lymph node status, and stage were collected. Treatments that patients received were reviewed, and patients’ breast-cancer specific survival and disease-free survival were evaluated. Results: A total of 1423 patients was enrolled in this study. 190 patients (13.4%) received surgery at over the age of 70. Luminal B was the most common subtype (n = 75, 39.5%) followed by luminal A subtype (n = 45, 23.7%). These patients mostly presented with stage 2 (38.4%) and stage 1 (36.3%) disease. 5-year breast cancer specific survival rate in older age group was 96%, while it was 99% for age group of 50–69 years old, with a significant statistical difference (p = 0.010). 5-year disease free survival also showed a statistically significant difference – 89% in the older age group and 94.4% in the younger age group. Conclusion(s): In older patients at or above the age of 70, 5-year disease free survival and breast cancer specific survival turned out lower than that of patients aged 50–69. With increasing life expectancy and improving health care, it may be time to reconsider what the most appropriate treatment for elderly breast cancer patients to ensure better survival and quality of life.

202303-01-01T00:00:00Z Lee, Anbok Kang, Taewoo Kang, Su Hwan Park, Woo-Chan Lim, Woosung Chang, Myung-Chul Kim, Hyun Yul Song, Jeong-yoon Lee, Jihyoun Byun, Kyung Do Kim, Hyun-Ah Son, Gil Soo Kim, Ju-Yeon Oh, Se Jeong Chung, Min Sung Choi, Young Jin Shin, Hyuk-Jai Baek, Jong Min Yoo, Youngbum Um, Eunhae Choi, Jin Hyuk Kwak, Beom Seok Park, Min Ho Lee, Suok Hyun Kim, Cheol Seung Lee, Ilkyun Kim, Je-Ryong Lee, Han Shin Lim, Cheol Wan https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64344 2025-09-25T06:30:12Z 2023-12-01T00:00:00Z

Title: An observational, prospective, open label, multicenter study to evaluate the safety and effectiveness of pegfilgrastim as secondary prophylaxis to decrease the incidence of febrile neutropenia in Korean female patients with breast cancer Authors: Lee, Anbok; Kang, Taewoo; Kang, Su Hwan; Park, Woo-Chan; Lim, Woosung; Chang, Myung-Chul; Kim, Hyun Yul; Song, Jeong-yoon; Lee, Jihyoun; Byun, Kyung Do; Kim, Hyun-Ah; Son, Gil Soo; Kim, Ju-Yeon; Oh, Se Jeong; Chung, Min Sung; Choi, Young Jin; Shin, Hyuk-Jai; Baek, Jong Min; Yoo, Youngbum; Um, Eunhae; Choi, Jin Hyuk; Kwak, Beom Seok; Park, Min Ho; Lee, Suok Hyun; Kim, Cheol Seung; Lee, Ilkyun; Kim, Je-Ryong; Lee, Han Shin; Lim, Cheol Wan Abstract: Purpose: Pegfilgrastim is a widely used long-acting granulocyte colony-stimulating factor (G-CSF) that prevents febrile neutropenia (FN) in patients with breast cancer receiving chemotherapy. This study aimed to evaluate the incidence of chemotherapy-related FN events and other adverse events (AEs) during chemotherapy in Korean patients with breast cancer treated with pegfilgrastim as secondary prophylactic support.Materials and methods: This was a multicenter, open-label, prospective, observational study. A total of 1255 patients were enrolled from 43 institutions. The incidence of FN was evaluated as the primary endpoint. The secondary endpoints included (1) incidence of bone pain, (2) proportion of patients with a relative dose intensity (RDI) of >= 85%, and (3) proportion of patients with AE. Results: Pegfilgrastim administration reduced FN by 11.8-1.6%. The highest incidence of bone pain was observed at the time point of the 1st day after the administration and mild bone pain was the most common of all bone pain severity. The mean RDI was 98.5 +/- 7.3%, and the proportion of the patients with and RDI >= 85% was 96.9% (1169/1233). AEs were reported in 52.6% of the patients, and serious drug reactions occurred in only 0.7%.Conclusion: The use of pegfilgrastim as secondary prophylaxis was effective and safe for preventing FN in patients with breast cancer who were treated with chemotherapy.

2023-12-01T00:00:00Z Yu, Da Young Chang, Young Woo Ku, Dohoe Ko, Seung Yeon Lee, Hye Yoon Son, Gil Soo https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64238 2024-07-11T10:00:50Z 2023-11-01T00:00:00Z

Title: Robotic thyroidectomy using gas-insufflation one-step single-port transaxillary (GOSTA) approach Authors: Yu, Da Young; Chang, Young Woo; Ku, Dohoe; Ko, Seung Yeon; Lee, Hye Yoon; Son, Gil Soo Abstract: BackgroundWe conducted this study to report our novel robotic thyroidectomy using gas-insufflation one-step single-port transaxillary (GOSTA) approach and compare it with a conventional transaxillary (CTA) approach using a retraction method for intraoperative and postoperative outcomes.MethodsWe retrospectively analyzed 354 patients who underwent robotic thyroidectomy between January 2019 and April 2023. Of these patients, 143 underwent the procedure through the GOSTA approach, which involves a small incision of 3 cm along the axillary folds with both arms down and a gas-insufflation, from skin flap creation to the completion of thyroidectomy as a one-step single-port procedure without the need for a retractor. The remaining 211 patients underwent the CTA approach. We analyzed the GOSTA approach and compared the surgical outcomes of the GOSTA (n = 100) and CTA (n = 167) approaches in patients with differentiated thyroid cancer who underwent thyroid lobectomy.ResultsOut of the 143 patients who underwent the GOSTA approach, 12 underwent total thyroidectomy and 9 underwent lateral neck lymph node dissection with total thyroidectomy. GOSTA-thyroid lobectomy was performed on 122 patients; of these, 100 were diagnosed with differentiated thyroid carcinoma. A comparative study with the CTA approach was only conducted in patients who underwent thyroid lobectomy. No significant differences were found in operative time, hospital stay, or complications between the two groups.ConclusionsDespite proceeding in one-step with a single smaller incision, from skin flap creation to the completion of thyroidectomy, the GOSTA approach is as feasible and safe as the CTA approach. Additionally, the GOSTA approach allows for thyroidectomy without using a retractor and reduces the workload for the surgeon and assistants.

2023-11-01T00:00:00Z Ko, Seung Yeon Chang, Young Woo Ku, Dohoe Yu, Da Young Lee, Hye Yoon Ji, Woong Bae Son, Gil Soo https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64141 2024-07-11T12:30:58Z 2023-08-01T00:00:00Z

Title: Comparison of robotic and laparoscopic lateral transperitoneal adrenalectomies Authors: Ko, Seung Yeon; Chang, Young Woo; Ku, Dohoe; Yu, Da Young; Lee, Hye Yoon; Ji, Woong Bae; Son, Gil Soo Abstract: Purpose: This study aimed to compare the intraoperative and postoperative outcomes between robotic and laparoscopic transperitoneal adrenalectomies. Methods: In this retrospective study, 93 patients underwent adrenalectomy using 2 surgical modalities: 45 patients underwent adrenalectomy using the da Vinci Xi system (robotic group), and 48 patients using laparoscopic devices (laparoscopic group). We compared the operation time, intraoperative bleeding, and hospital stay according to the surgical modality and tumor characteristics. Results: There were no significant differences in the operative time (P = 0.827), hospital stay (P = 0.177), and intraoperative bleeding (P = 0.174) between the groups. However, the robotic group showed a lower coefficient of variation in total operative time than that of the laparoscopic group (100.6 +/- 23.3 minutes vs. 101.9 +/- 32.7 minutes, 0.230 vs. 0.321). When divided into 2 subgroups based on the tumor size (> 3 cm and >= 3 cm), the robotic group with a tumor sized > 3 cm had a shorter operative time than that of the laparoscopic group (P = 0.032). The robotic group also had fewer cases of intraoperative bleeding (P = 0.034). Conclusions: Compared to the laparoscopic transperitoneal adrenalectomy, the robotic one achieved a lower deviation in total operative time and showed less bleeding and a shorter operative time, especially for tumors sized > 3 cm.

2023-08-01T00:00:00Z