https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/112 2026-04-04T13:27:59Z 2026-04-04T13:27:59Z Leea, Jae-woo Roh, Seung-Young Yoon, Woong-Su Kim, Jinseob Jo, Eunseo Bae, Dae-Hwan Kim, Min Lee, Ju-Hee Kim, Sang Min Choi, Woong Gil Bae, Jang-Whan Hwang, Kyung-Kuk Kim, Dong-Woon Cho, Myeong-Chan Kim, Ye-Seul Kim, Yonghwan You, Hyo-Sun Kan, Hee-Taik Lee, Dae-In https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64138 2024-07-11T12:00:45Z 2024-01-01T00:00:00Z

Title: Changes in alcohol consumption habits and risk of atrial fibrillation: a nationwide population-based study Authors: Leea, Jae-woo; Roh, Seung-Young; Yoon, Woong-Su; Kim, Jinseob; Jo, Eunseo; Bae, Dae-Hwan; Kim, Min; Lee, Ju-Hee; Kim, Sang Min; Choi, Woong Gil; Bae, Jang-Whan; Hwang, Kyung-Kuk; Kim, Dong-Woon; Cho, Myeong-Chan; Kim, Ye-Seul; Kim, Yonghwan; You, Hyo-Sun; Kan, Hee-Taik; Lee, Dae-In Abstract: Aims Heavy alcohol consumption is an established risk factor for atrial fibrillation (AF). However, the association between habitual changes in heavy habitual drinkers and incident AF remains unclear. The aim of this study was to evaluate whether absolute abstinence or reduced drinking decreases incident AF in heavy habitual drinkers. Methods and results Atrial fibrillation-free participants with heavy alcohol consumption registered in the Korean National Health Insurance Service database between 2005 and 2008 were enrolled. Habitual changes in alcohol consumption between 2009 and 2012 were classified as sustained heavy drinking, reduced drinking, and absolute abstinence. The primary outcome measure was new-onset AF during the follow-up. To minimize the effect of confounding variables on outcome events, inverse probability of treatment weighting (IPTW) analysis was performed. Overall, 19 425 participants were evaluated. The absolute abstinence group showed a 63% lower incidence of AF (IPTW hazard ratio: 0.379, 95% confidence interval: 0.1690.853) than did the sustained heavy drinking group. Subgroup analysis identified that abstinence significantly reduced incident AF in participants with normal body mass index and without hypertension, diabetes, dyslipidaemia, heart failure, stroke, chronic kidney disease, or coronary artery disease (all P-value < 0.05). There was no statistical difference in incident AF in participants with reduced drinking compared with sustained heavy alcohol group. Conclusion Absolute abstinence could reduce the incidence of AF in heavy alcohol drinkers. Comprehensive clinical measures and public health policies are warranted to motivate alcohol abstinence in heavy drinkers.

2024-01-01T00:00:00Z Lee, Jieun Baek, Man-Jong Choi, Jah Yeon https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64328 2024-07-11T09:34:31Z 2024-01-01T00:00:00Z

Title: Ventricular septal defect combined with double-chambered right ventricle and severe right ventricular outflow tract stenosis in a symptom-free septuagenarian Authors: Lee, Jieun; Baek, Man-Jong; Choi, Jah Yeon Abstract: [No abstract available]

2024-01-01T00:00:00Z Lee, Sang Hyuk Back, Ji Hyun Joo, Hyung Joon Lim, Do-Sun Lee, Ji Eun Lee, Hye Jin https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64409 2024-07-11T09:33:44Z 2024-01-01T00:00:00Z

Title: Simultaneous detection method for two cardiac disease protein biomarkers on a single chip modified with mixed aptamers using surface plasmon resonance Authors: Lee, Sang Hyuk; Back, Ji Hyun; Joo, Hyung Joon; Lim, Do-Sun; Lee, Ji Eun; Lee, Hye Jin Abstract: A simultaneous detection method for two cardiac disease protein biomarkers present in serum samples on a single planar gold chip using surface plasmon resonance (SPR) is described. The detection of N-terminal pro -brain natriuretic peptide (NT-proBNP) and tumor necrosis factor alpha (TNF-alpha), which are known as acute myocardial infarction (AMI) biomarkers, with predetermined clinically relevant concentrations was performed using mixed aptamers specific to each protein tethered on a single gold surface. After the binding of NT-proBNP and/or TNF-alpha to the mixed aptamers, an antibody specific to each target protein was injected to form a surface sandwich complex to improve selectivity. In order to adjust the dynamic ranges in the known clinically relevant concentration significantly different for NT-proBNP (0.13-0.24 nM) and TNF-alpha (0.5-3 pM), the surface density ratios of the corresponding pair of aptamer and antibody were first systematically determined, which were the 1:1 mixed aptamer chip with 40 nM anti-NT-proBNP and 100 nM anti-TNF-alpha. This allowed to establish the distinct dynamic ranges of 0.05-0.5 nM for NT-proBNP and 0.1-5 pM for TNF-alpha in a buffer, along with detection and quantification limits of 0.03 and 0.19 nM for NT-proBNP and 0.06 and 0.21 pM for TNF-alpha, respectively. The changes in refractive unit (RU) values observed when exposing both proteins at different concentrations alongside the corresponding fixed concentration of antibodies onto the 1:1 mixed aptamer chip were then correlated to the sum of RU values measured when using the injection of individual protein for evaluating each protein concentration. With a complete characterization of the simultaneous quantification of two protein concentrations in the buffer, the mixed aptamer chip was finally employed for direct measurements of NT-proBNP and TNF-alpha concentrations in undiluted serum samples from healthy controls and AMI patients. The results of simultaneous SPR measurements for the two proteins in the serum samples were further compared to the individual protein concentration results using an enzyme-linked immunosorbent assay.

2024-01-01T00:00:00Z Kim, Min Bae, Dae-Hwan Lee, Ju Hee Lee, Dae In Kim, Sang Min Lee, Sang Yeub Bae, Jang-Whan Kim, Dong-Woon Cho, Myeong-Chan Hwang, Jin Yong Oh, Seok Kyu Cha, Kwang Soo Choi, Cheol Ung Gwon, Hyeon Cheol Jeong, Myung Ho Hwang, Kyung-Kuk https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62352 2024-05-16T05:30:40Z 2024-01-01T00:00:00Z

Title: Impact of multivessel versus single-vessel disease on the association between low diastolic blood pressure and mortality after acute myocardial infarction with revascularization Authors: Kim, Min; Bae, Dae-Hwan; Lee, Ju Hee; Lee, Dae In; Kim, Sang Min; Lee, Sang Yeub; Bae, Jang-Whan; Kim, Dong-Woon; Cho, Myeong-Chan; Hwang, Jin Yong; Oh, Seok Kyu; Cha, Kwang Soo; Choi, Cheol Ung; Gwon, Hyeon Cheol; Jeong, Myung Ho; Hwang, Kyung-Kuk Abstract: Background Previous studies demonstrated a J-shaped relationship between low diastolic blood pressure (DBP) and adverse clinical outcomes in patients with acute myocardial infarction (AMI) that was sensitive to revascularization. Hypothesized herein, was that this relationship differs between patients with multivessel disease (MVD) and those with single-vessel disease due to differing degrees of myocardial ischemic burden. Methods Among 9,983 AMI patients from the Korea Acute Myocardial Infarction Registry database who underwent percutaneous coronary intervention and were followed up for a median duration of 3.2 years, average on-treatment DBP was calculated at admission, discharge, and every scheduled visit and divided into these parameters: < 70 mmHg, 70-74 mmHg, 75-79 mmHg, and >= 80 mmHg. The relationship between average on-treatment DBP and clinical outcomes including all-cause death, cardiovascular (CV) death, non-CV death, and hospitalization for heart failure was analyzed using the Cox regression models adjusted for clinical covariates. Results In patients with MVD, all-cause death (hazard ratio [HR]: 1.47; 95% confidence interval [CI]: 1.06-2.04, p = 0.012) and CV death (HR: 1.59; 95% CI: 1.02-2.46, p = 0.027) were significantly increased in patients with a DBP < 70 mmHg, showing a J-shaped relationship. However, these findings were not significant for single-vessel disease. On a sensitivity analysis excluding subjects with a baseline SBP < 120 mmHg, an increased risk of a low DBP < 70 mmHg remained in MVD. Conclusions The J-shaped relationship between low DBP and adverse clinical outcomes in AMI patients who underwent revascularization persisted in MVD, which has a high ischemic burden. These high-risk patients require cautious treatment. (Cardiol J)

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