ScholarWorks Community:https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1422024-03-28T19:40:01Z2024-03-28T19:40:01ZThree-dimensional imaging and quantification of epidermal innervation in atopic dermatitisKim, D.Lee, S.Seo, S.Ahn, H.Sun, W.Kim, B.Rhyu, I.https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/640652023-12-27T01:01:59Z202305-01-01T00:00:00ZTitle: Three-dimensional imaging and quantification of epidermal innervation in atopic dermatitis
Authors: Kim, D.; Lee, S.; Seo, S.; Ahn, H.; Sun, W.; Kim, B.; Rhyu, I.
Abstract: Understanding the structural alteration of epidermal innervation is essential for a deeper understanding of neurogenic inflammation and pruritus in atopic dermatitis. The skin of atopic dermatitis patients has been reported to show controversial results, higher or lower intraepidermal nerve fiber densities (IENFDs). Therefore, this study was intended to verify the genuine structural alteration of epidermal innervation in atopic dermatitis through the skin-clearing technique and related three-dimensional (3-D) image quantification process as previously reported. A total of 10 (five healthy and five atopic dermatitis subjects) participants were prospectively enrolled. All subjects were male, 20s, and received biopsy/suction blister on a similar anatomical site, proximal forearm, to control other variables which could affect the results of IENFDs. The atopic dermatitis patients displayed significantly decreased intraepidermal nerve fibers, nodes, end, total length, total volume, and complexity compared with the results of healthy subjects. Furthermore, the arborizing intermingled structures of healthy subjects represented by nodes and complexity seemed to be more vividly simplified in the atopic dermatitis patients compared with the degree of decrease of well-known parameters, number of nerve fibers, or total length. In conclusion, our study successfully demonstrated the difference of 3-D whole structural images of epidermal innervation between healthy subjects and atopic dermatitis patients. Further studies with a larger number of participants are expected to show the possible relationship among structural alteration of epidermal innervation, neurosensory symptoms, and neurogenic inflammation of atopic dermatitis.202305-01-01T00:00:00ZPeriodontal disease does not increase the risk of subsequent psoriasisBaek, Yoo SangKwak, Eun-JungKim, Young ChanKim, Ko EunSong, Hae JunJeon, Jiehyunhttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/638122023-12-19T05:00:52Z2023-12-01T00:00:00ZTitle: Periodontal disease does not increase the risk of subsequent psoriasis
Authors: Baek, Yoo Sang; Kwak, Eun-Jung; Kim, Young Chan; Kim, Ko Eun; Song, Hae Jun; Jeon, Jiehyun
Abstract: Previous studies suggested that chronic periodontitis may be a risk factor for psoriasis. However, no study has confirmed this relationship for all stages of periodontal disease (gingivitis and periodontitis). This nationwide population-based retrospective cohort study aimed to investigate whether periodontal disease is an independent risk factor for the development of subsequent psoriasis. Patients aged >= 20 years who underwent both medical and oral checkups from the National Health Screening Program between 2002 and 2007 were selected from a customized database provided by the National Health Insurance Service (NHIS). Then, patients with periodontal disease (n=3,682,468) and without periodontal disease (control, n=3,637,128) according to oral examination results were identified. We tracked each patient for subsequent psoriasis diagnosis until the end of 2018 using NHIS database. The incidence rates of psoriasis per 1000 person-years were 0.36 and 0.34 in the periodontal disease group and control groups, respectively. After adjusting for potential cofactors, no significant increase in risk (adjusted hazard ratio, 0.994; 95% confidence interval, 0.974-1.015) was observed. Similar results were observed when analyzing the risk of psoriasis in patients who required scaling or periodontal surgery. In conclusion, periodontal disease is not an independent risk factor of psoriasis.2023-12-01T00:00:00ZIncreased dental comorbidities in patients with psoriasis: a nationwide population-based cohort study in KoreaKwak, Eun-JungChoi, Yun JinKim, Han-NaKim, Ko EunJeon, JiehyunBaek, Yoo Sanghttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/642812024-02-20T11:30:23Z2023-11-01T00:00:00ZTitle: Increased dental comorbidities in patients with psoriasis: a nationwide population-based cohort study in Korea
Authors: Kwak, Eun-Jung; Choi, Yun Jin; Kim, Han-Na; Kim, Ko Eun; Jeon, Jiehyun; Baek, Yoo Sang
Abstract: Background Limited data are available regarding the association between psoriasis and common dental conditions.Objectives To investigate the risk of potential dental comorbidities in patients with psoriasis.Methods We conducted a nationwide population-based cohort study to analyse the claims data of patients with psoriasis (n = 15 165) and age- and sex-matched controls (n = 75 825). The incidence risk of the following potential dental conditions was analysed: dental caries, pulp and periapical disease, periodontal disease, gingival changes and tooth loss.Results After adjusting for potential cofactors, the adjusted hazard ratios (aHRs) of dental caries [1.105; 95% confidence interval (CI) 1.078-1.132], pulp and periapical disease (1.07; 95% CI 1.044-1.096) and periodontal disease (1.108; 95% CI 1.088-1.129) were significantly higher than those in the control cohort (P < 0.001). However, among the subset of patients with psoriasis who received systemic antipsoriatic treatment (n = 4275), the aHR risk of all potential dental comorbidities was not significantly higher from that of the control cohort.Conclusions Patients with psoriasis have an increased risk of dental comorbidities, and systemic antipsoriatic treatment may help mitigate this increased risk.2023-11-01T00:00:00ZHospital Utilization and Medication Prescriptions among Patients with Atopic Dermatitis in South Korea: A Real-World Data AnalysisLee, Ji HyunNoh, YunhaChoi, AhhyungOh, In -SunJeon, Ja-YoungYoo, Hyun-JeongShin, Ju-YoungSon, Sang Wookhttps://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/643332023-12-15T06:15:46Z2023-10-01T00:00:00ZTitle: Hospital Utilization and Medication Prescriptions among Patients with Atopic Dermatitis in South Korea: A Real-World Data Analysis
Authors: Lee, Ji Hyun; Noh, Yunha; Choi, Ahhyung; Oh, In -Sun; Jeon, Ja-Young; Yoo, Hyun-Jeong; Shin, Ju-Young; Son, Sang Wook2023-10-01T00:00:00Z