https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/293 2026-04-04T10:49:50Z 2026-04-04T10:49:50Z Seo, Kyoungsan Kim, Se-an Choe, Young June Moon, Jihyun https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63832 2025-09-19T07:30:10Z 2025-04-01T00:00:00Z

Title: School Nurses' Experiences and Needs in COVID-19 Pandemic Response: A Qualitative Study Authors: Seo, Kyoungsan; Kim, Se-an; Choe, Young June; Moon, Jihyun Abstract: The coronavirus disease 2019 pandemic drastically shifted the public health burden onto the school health system. We, therefore, explored the school nurses' experiences and needs for confronting the pandemic in school settings across Korea. This qualitative investigation enrolled 30 participants after their written consent. A written interview conducted through email and focus group interviews using an online meeting application verified participants' opinions and experiences. Collected data were subjected to text-mining and content analysis. The school nurse was found to be responsible for many tasks, including education on preventive measures with unclear quarantine guidelines. Content analysis identified three key themes: "aggravated difficulties owing to lack of support resulted in burnout," "reflection on supportive resources; direct provisions were helpful," and "needs and suggestions to safeguard students' health in the event of another pandemic." Recommendations should all be considered to keep schools and students safe from future pandemics.

2025-04-01T00:00:00Z Baek, Hee Sun Park, Min Ji Song, Ji Yeon Kim, Seong Heon Kang, Hee Gyung Ahn, Yo Han Han, Kyoung Hee Cho, Heeyeon Lee, Keum Hwa Shin, Jae Il Park, Young Seo Lee, Joo Hoon Park, Eujin Yang, Eun Mi Cho, Min Hyun https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63582 2024-07-11T10:00:51Z 2023-12-01T00:00:00Z

Title: Association between serum total cholesterol and chronic kidney disease progression in children: results from the KNOW-PedCKD Authors: Baek, Hee Sun; Park, Min Ji; Song, Ji Yeon; Kim, Seong Heon; Kang, Hee Gyung; Ahn, Yo Han; Han, Kyoung Hee; Cho, Heeyeon; Lee, Keum Hwa; Shin, Jae Il; Park, Young Seo; Lee, Joo Hoon; Park, Eujin; Yang, Eun Mi; Cho, Min Hyun Abstract: Background Dyslipidemia can cause cardiovascular disease and increase the fatality rate among children with chronic kidney disease (CKD); this makes early screening and treatment of dyslipidemia crucial. This study aimed to assess the association between the changes in serum total cholesterol levels over time and the degree of CKD progression in children. Methods From April 2011 to August 2021, 379 of the 432 participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric CKD (KNOW-PedCKD) were included and divided into 4 categories based on total cholesterol levels (< 170 mg/dL, acceptable; 170–199, borderline; 200–239, high; and ≥ 240, very high). Survival analysis using conventional and time-dependent Cox proportional hazards model were performed for a composite event of CKD progression (≥ 50% decrease in estimated glomerular filtration rate from baseline, a twofold increase in creatinine, or the occurrence of dialysis or kidney transplantation). Result The incidence of composite event of CKD progression was 96.3, 90.4, 87.3, and 270.6 cases per 1000 person-years in the acceptable, borderline, high, and very high categories, respectively. On using the time-dependent Cox proportional hazards model, the hazard ratio of the very high category was significantly higher than that of the acceptable category by 3.13 times as per univariate analysis and 2.37 times as per multivariate analysis. Conclusions Very high serum total cholesterol is a significant risk factor for CKD progression in children. Lowering total cholesterol levels below the very high category in children with CKD may delay the progression of CKD.

2023-12-01T00:00:00Z Kim, Jae-Jung Hong, Young Mi Yun, Sin Weon Lee, Kyung-Yil Yoon, Kyung Lim Han, Myung-Ki Kim, Gi Beom Kil, Hong-Ryang Song, Min Seob Lee, Hyoung Doo Ha, Kee Soo Jun, Hyun Ok Yu, Jeong Jin Jang, Gi Young Lee, Jong-Keuk https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64297 2025-05-01T06:30:08Z 2023-10-01T00:00:00Z

Title: Identification of B-cell-related<i> HSPG2</i> and<i> CDSN</i> as susceptibility loci for Kawasaki disease Authors: Kim, Jae-Jung; Hong, Young Mi; Yun, Sin Weon; Lee, Kyung-Yil; Yoon, Kyung Lim; Han, Myung-Ki; Kim, Gi Beom; Kil, Hong-Ryang; Song, Min Seob; Lee, Hyoung Doo; Ha, Kee Soo; Jun, Hyun Ok; Yu, Jeong Jin; Jang, Gi Young; Lee, Jong-Keuk Abstract: Kawasaki disease (KD) is an acute pediatric vasculitis that predominantly affects children under the age of 5 years. To date, genome-wide association studies (GWAS) have identified several KD susceptibility genes (e.g., BLK, CD40, FCGR2A, BCL2L11, and IGHV), which are mainly involved in B cell immunity. In this study, we aimed to identify additional KD susceptibility genes mainly involved in B cell development and functions by analyzing our previous GWAS data and conducting a replication study using new sample. Initially, we selected 30 single nucleotide polymorphisms (SNPs) in B-cell-related genes that were significantly (P < 0.01) associated with KD in our previous GWAS analysis of 247 KD cases with complete type and 1,000 healthy controls. Replication study was performed by genotyping the new 837 KD case samples with Fluidigm system and comparing them with 3,553 control genotypes. Among the 30 candidate SNPs, two were significantly associated with KD (P 0.001) in the replication study. An even greater association between these SNPs and KD was observed in the combined analysis of GWAS and replication samples: odds ratio (OR) = 1.97 (P = 8.61 x 10-6) for rs2270699 (nonsynonymous SNP: c.10588C T, p.Arg3530Trp) in the heparan sulfate proteoglycan 2 (HSPG2) gene and OR = 1.28 (P = 1.34 x 10-6) for rs3130992 (intronic SNP) in both the corneodesmosin (CDSN) and psoriasis susceptibility 1 candidate 1 (PSORS1C1) genes. These results suggest that the B-cell related genes, HSPG2 and CDSN or PSORS1C1, play a role in the development of KD.

2023-10-01T00:00:00Z Lee, Eun Rhee, Eun Hee Kim, Kyunghoon Kim, Hwan Soo Kim, Woo Kyung Song, Dae Jin Park, Ji Soo Yoo, Young Suh, Dong In Jung, Sungsu Yoon, Ji-Sun Lee, Seung Won Kim, Jin Tack Lim, Dae Hyun Baek, Hey Sung Shin, Meeyong Kwon, Ji Won Jang, Gwang Cheon Seo, Ju Hee Woo, Sung Il Kim, Hyung Young Shin, Youn Ho Lee, Ju Suk Yang, Hyeon-Jong Yu, Jinho https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64310 2024-07-11T10:30:35Z 2023-10-01T00:00:00Z

Title: Frequency of exacerbation and degree of required asthma medication can characterize childhood longitudinal asthma trajectories Authors: Lee, Eun; Rhee, Eun Hee; Kim, Kyunghoon; Kim, Hwan Soo; Kim, Woo Kyung; Song, Dae Jin; Park, Ji Soo; Yoo, Young; Suh, Dong In; Jung, Sungsu; Yoon, Ji-Sun; Lee, Seung Won; Kim, Jin Tack; Lim, Dae Hyun; Baek, Hey Sung; Shin, Meeyong; Kwon, Ji Won; Jang, Gwang Cheon; Seo, Ju Hee; Woo, Sung Il; Kim, Hyung Young; Shin, Youn Ho; Lee, Ju Suk; Yang, Hyeon-Jong; Yu, Jinho Abstract: Background: To the best of our knowledge, there have been no investigations of longitudinal asthma trajectories based on asthma exacerbation frequency and medications required for asthma control in children. Objective: To investigate longitudinal asthma trajectories based on the exacerbation frequency throughout childhood and asthma medication ranks.Methods: A total of 531 children aged 7 to 10 years were enrolled from the Korean childhood Asthma Study. Required asthma medications for control of asthma from 6 to 12 years of age and asthma exacerbation frequency from birth to 12 years of age were obtained from the Korean National Health Insurance System database. Longitudinal asthma trajectories were identified on the basis of asthma exacerbation frequency and asthma medication ranks.Results: Four asthma clusters were identified: lesser exacerbation with low-step treatment (8.1%), lesser exacerbations with middle-step treatment (30.7%), highly frequent exacerbations in early childhood with small-airway dysfunction (5.7%), and frequent exacerbations with high-step treatment (55.6%). The frequent exacerbations with high-step treatment cluster were characterized by a high prevalence of male sex, increased blood eosinophil (counts) with fractional exhaled nitric oxide, and high prevalence of comorbidities. The highly frequent exacerbation in early childhood with small-airway dysfunction cluster was characterized by recurrent wheeze in preschool age, with high prevalence of acute bronchiolitis in infancy and a greater number of family members with small-airway dysfunction at school age.Conclusion: The present study identified 4 longitudinal asthma trajectories on the basis of the frequency of asthma exacerbation and asthma medication ranks. These results would help clarify the heterogeneities and pathophysiologies of childhood asthma. (c) 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

2023-10-01T00:00:00Z