ScholarWorks Community:
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/328
2024-03-29T14:49:19Z
2024-03-29T14:49:19Z
Association of metabolic dysfunction with cognitive decline and Alzheimer's disease: A review of metabolomic evidence
Amidfar, Meysam
Askari, Gholamreza
Kim, Yong-Ku
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64115
2023-12-15T06:14:59Z
2024-01-01T00:00:00Z
Title: Association of metabolic dysfunction with cognitive decline and Alzheimer's disease: A review of metabolomic evidence
Authors: Amidfar, Meysam; Askari, Gholamreza; Kim, Yong-Ku
Abstract: The discovery of new biomarkers that can distinguish Alzheimer's disease (AD) from mild cognitive impairment (MCI) in the early stages will help to provide new diagnostic and therapeutic strategies and slow the transition from MCI to AD. Patients with AD may present with a concomitant metabolic disorder, such as diabetes, obesity, and dyslipidemia, as a risk factor for AD that may be involved in the onset of both AD pathology and cognitive impairment. Therefore, metabolite profiling, or metabolomics, can be very useful in diagnosing AD, developing new therapeutic targets, and evaluating both the course of treatment and the clinical course of the disease. In addition, studying the relationship between nutritional behavior and AD requires investigation of the role of conditions such as obesity, hypertension, dyslipidemia, and elevated glucose level. Based on this literature review, nutritional recommendations, including weight loss by reducing calorie and cholesterol intake and omega3 fatty acid supplementation can prevent cognitive decline and dementia in the elderly. The underlying metabolic causes of the pathology and cognitive decline caused by AD and MCI are not well understood. In this review article, metabolomics biomarkers for diagnosis of AD and MCI and metabolic risk factors for cognitive decline in AD were evaluated.
2024-01-01T00:00:00Z
Functional connectivity and network analysis in adolescents with major depressive disorder showing suicidal behavior
Chi, Suhyuk
Mok, Young Eun
Lee, Jong-ha
Suh, Sang-il
Han, Changsu
Lee, Moon-Soo
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64361
2023-12-19T04:30:47Z
2023-12-01T00:00:00Z
Title: Functional connectivity and network analysis in adolescents with major depressive disorder showing suicidal behavior
Authors: Chi, Suhyuk; Mok, Young Eun; Lee, Jong-ha; Suh, Sang-il; Han, Changsu; Lee, Moon-Soo
Abstract: Background: This study aimed to gather a homogeneous sample of adolescent patients to analyze the differences in functional connectivity and brain network pa-rameters between suicidal and non-suicidal major depressive disorder (MDD) patients using a data-driven whole-brain approach.Methods: Patients recruited at the psychiatry department of Korea University Guro Hospital from November 2014 to March 2020 were diagnosed with MDD, were 13-18 years old, had IQ scores >80, had no family history of psychotic or personality disorders, had no smoking or alcohol consumption history, and were drug-naive to psychotropic medication. Depressive symptoms were assessed using the Hamilton Depression Rating Scale and the Children's Depression Inventory. Structural and functional MRI scans were conducted and analyzed using the CONN toolbox.Results: Of 74 enrolled patients, 62 were analyzed. Regions of interest (ROIs) showing higher betweenness centrality in non-suicidal patients were the left superior temporal gyrus and left supramarginal gyrus. ROIs showing higher betweenness centrality in suicidal patients were the right hippocampus, left intracalcarine cortex, right inferior temporal gyrus, and the lateral visual network. Suicidal patients also showed different resting state functional connectivity profiles from non-suicidal patients.Limitations: Small sample size.Conclusion: Suicidal patients may overthink and overvalue future risks while having a more negatively biased autobiographical memory. Social cognition and the ability to overcome egocentricity bias seem to weaken. Such features can disrupt cognitive recovery and resilience, leading to more suicidal behaviors. Therefore, increased suicidality is not acquired, but is an innate trait.
2023-12-01T00:00:00Z
Reliability and Validity of the Korean Version of the Brief Resilience Scale
Kim, Junhyung
Jeong, Hyun-Ghang
Lee, Moon-Soo
Lee, Seung-Hoon
Jeon, Sang-Won
Han, Changsu
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64398
2023-12-19T04:30:42Z
2023-11-01T00:00:00Z
Title: Reliability and Validity of the Korean Version of the Brief Resilience Scale
Authors: Kim, Junhyung; Jeong, Hyun-Ghang; Lee, Moon-Soo; Lee, Seung-Hoon; Jeon, Sang-Won; Han, Changsu
Abstract: Objective: To translate the Brief Resilience Scale into Korean and evaluate its reliability and validity.Methods: To investigate the factor structure of the Brief Resilience Scale, we examined a two-factor model comprising positively and negatively worded items. Congruent and divergent validity of the Brief Resilience Scale were investigated using correlation analysis between the Brief Resilience Scale and resilience, depression, and perceived stress. By conducting an analysis of variance among groups classified by suicidality (no suicidality, only suicidal ideation, and suicidal ideation or suicidal plan groups), we evaluated how well the Brief Resilience Scale could detect people with a high risk of suicide.Results: Confirmatory factor analysis results supported the construct validity of the Brief Resilience Scale using a two-factor model. Cronbach's alpha (0.91) and McDonald's omega (0.91) scores indicated high internal consistency. Correlation analysis showed that the Brief Resilience Scale scores were strongly associated with a questionnaire evaluating resilience, depression, and perceived stress. Analysis of variance and post-hoc tests showed that he Brief Resilience Scale scores were highest in the no suicidality group (p < 0.001).Conclusion: The Korean version of the Brief Resilience Scale is a valid and reliable instrument for evaluating resilience as the capacity to recover from adversity and endure obstacles or stress. This study also provides important evidence regarding the sensitivity of the Brief Resilience Scale to suicidal risk.
2023-11-01T00:00:00Z
Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
Nguyen, Lan Phuong
Cho, Minyeong
Nguyen, Thai Uy
Park, Hee-Kyung
Nguyen, Huong Thi
Mykhailova, Kateryna
Hurh, Sunghoon
Kim, Hong-Rae
Seong, Jae Young
Lee, Cheol Soon
Ham, Byung-Joo
Hwang, Jong-Ik
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64389
2023-12-19T04:30:44Z
2023-11-01T00:00:00Z
Title: Neurokinin-2 receptor negatively modulates substance P responses by forming complex with Neurokinin-1 receptor
Authors: Nguyen, Lan Phuong; Cho, Minyeong; Nguyen, Thai Uy; Park, Hee-Kyung; Nguyen, Huong Thi; Mykhailova, Kateryna; Hurh, Sunghoon; Kim, Hong-Rae; Seong, Jae Young; Lee, Cheol Soon; Ham, Byung-Joo; Hwang, Jong-Ik
Abstract: Background: Tachykinins and their cognate receptors, neurokinin receptors (NKs) including NK1, NK2, and NK3 play vital roles in regulating various physiological processes including neurotransmission, nociception, inflammation, smooth muscle contractility, and stimulation of endocrine and exocrine gland secretion. Their abnormal expression has been reported to be associated with neurological disorders, inflammation, and cancer. Even though NKs are expressed in the same cells with their expression being inversely correlated in some conditions, there is no direct evidence to prove their interaction. Understanding the functional crosstalk between NKs in mediated downstream signaling and cellular responses may elucidate the roles of each receptor in pathophysiology. Results: In this study, we showed that NKs were co-expressed in some cells. However, different from NK3, which only forms homodimerization, we demonstrated a direct interaction between NK1 and NK2 at the protein level using co-immunoprecipitation and NanoBiT-based protein interaction analysis. Through heterodimerization, NK2 downregulated substance P-stimulated NK1 signals, such as intracellular Ca2+ mobilization and ERK phosphorylation, by enhancing β-arrestin recruitment, even at the ligand concentration that could not activate NK2 itself or in the presence of NK1 specific antagonist, aprepitant. In A549 cells with receptors deleted and reconstituted, NK2 exerted a negative effect on substance P/NK1-mediated cell migration. Conclusion: Our study has provided the first direct evidence of an interaction between NK1 and NK2, which highlights the functional relevance of their heterodimerization in cellular responses. Our findings demonstrated that through dimerization, NK2 exerts negative effects on downstream signaling and cellular response mediated by NK1. Moreover, this study has significant implications for understanding the complexity of GPCR dimerization and its effect on downstream signaling and cellular responses. Given the important roles of tachykinins and NKs in pathophysiology, these insights may provide clues for developing NKs-targeting drugs. © 2023, The Author(s).
2023-11-01T00:00:00Z