https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/382 2026-01-02T09:29:39Z 2026-01-02T09:29:39Z Chung, Eric Hui, Jiang Xin, Zhong Cheng Kim, Sae Woong Moon, Du Geon Yuan, Yiming Nagao, Koichi Hakim, Lukman Chang, Hong-Chiang Mak, Siu King Duarsa, Gede Wirya Kusuma Dai, Yutian Yao, Bing Son, Hwancheol Huang, William Lin, Haocheng Nguyen, Quang Mai, Dung Ba Tien Park, Kwangsung Lee, Joe Tantiwongse, Kavirach Sato, Yoshikazu Jiann, Bang-Ping Ho, Christopher Park, Hyun Jun https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64375 2024-12-14T02:30:29Z 2024-07-01T00:00:00Z

Title: Management of Male Infertility with Coexisting Sexual Dysfunction: A Consensus Statement and Clinical Recommendations from the Asia-Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men's Health and Aging (ASMHA) Authors: Chung, Eric; Hui, Jiang; Xin, Zhong Cheng; Kim, Sae Woong; Moon, Du Geon; Yuan, Yiming; Nagao, Koichi; Hakim, Lukman; Chang, Hong-Chiang; Mak, Siu King; Duarsa, Gede Wirya Kusuma; Dai, Yutian; Yao, Bing; Son, Hwancheol; Huang, William; Lin, Haocheng; Nguyen, Quang; Mai, Dung Ba Tien; Park, Kwangsung; Lee, Joe; Tantiwongse, Kavirach; Sato, Yoshikazu; Jiann, Bang-Ping; Ho, Christopher; Park, Hyun Jun Abstract: Male infertility (MI) and male sexual dysfunction (MSD) can often coexist together due to various interplay factors such as psychosexual, sociocultural and relationship dynamics. The presence of each form of MSD can adversely impact male reproduction and treatment strategies will need to be individualized based on patients' factors, local expertise, and geographical socioeconomic status. The Asia Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men's Health and Aging (ASMHA) aim to provide a consensus statement and practical set of clinical recommendations based on current evidence to guide clinicians in the management of MI and MSD within the Asia-Pacific (AP) region. A comprehensive, narrative review of the literature was performed to identify the various forms of MSD and their association with MI. MEDLINE and EMBASE databases were searched for the following English language articles under the following terms: "low libido", "erectile dysfunction", "ejaculatory dysfunction", "premature ejaculation", "retrograde ejaculation", "delayed ejaculation", "anejaculation", and "orgasmic dysfunction" between January 2001 to June 2022 with emphasis on published guidelines endorsed by various organizations. This APSSM consensus committee panel evaluated and provided evidence-based recommendations on MI and clinically relevant MSD areas using a modified Delphi method by the panel and specific emphasis on locoregional socioeconomic-cultural issues relevant to the AP region. While variations exist in treatment strategies for managing MI and MSD due to geographical expertise, locoregional resources, and sociocultural factors, the panel agreed that comprehensive fertility evaluation with a multidisciplinary management approach to each MSD domain is recommended. It is important to address individual MI issues with an emphasis on improving spermatogenesis and facilitating reproductive avenues while at the same time, managing various MSD conditions with evidence-based treatments. All therapeutic options should be discussed and implemented based on the patient's individual needs, beliefs and preferences while incorporating locoregional expertise and available resources.

2024-07-01T00:00:00Z Agarwal, Ashok Farkouh, Ala'a Saleh, Ramadan Hamoda, Taha Abo-Almagd Abdel-Meguid Salvio, Gianmaria Boitrelle, Florence Harraz, Ahmed M. Abou Ghayda, Ramy Kavoussi, Parviz Gul, Murat Toprak, Tuncay Russo, Giorgio Ivan Durairajanayagam, Damayanthi Rambhatla, Amarnath Birowo, Ponco Cannarella, Rossella Nguyen Ho Vinh Phuoc Zini, Armand Arafa, Mohamed Wyns, Christine Tremellen, Kelton Sarikaya, Selcuk Lewis, Sheena Evenson, Donald P. Ko, Edmund Calogero, Aldo E. Bahar, Fahmi Martinez, Marlon Ambar, Rafael F. Colpi, Giovanni M. Bakircioglu, Mustafa Emre Henkel, Ralf Kandil, Hussein Serefoglu, Ege Can Alfakhri, Abdullah Tsujimura, Akira Kheradmand, Alireza Marino, Angelo Adamyan, Aram Zilaitiene, Birute Ozer, Cevahir Pescatori, Edoardo Vogiatzi, Paraskevi Busetto, Gian Maria Balercia, Giancarlo Elbardisi, Haitham Akhavizadegan, Hamed Sajadi, Hesamoddin Taniguchi, Hisanori Park, Hyun Jun Rosas, Israel Maldonado Al-Marhoon, Mohamed Gilani, Mohammad Ali Sadighi Alhathal, Naif Nguyen Quang Pinggera, Germar-Michael Kothari, Priyank Micic, Sava Homa, Sheryl Tran Quang Tien Long Zohdy, Wael Atmoko, Widi Ibrahim, Wael Sabbaghian, Marjan Abumelha, Saad Mohammed Chung, Eric Ugur, Muhammet Rasit Ozkent, Mehmet Serkan Selim, Osama Darbandi, Mahsa Fukuhara, Shinichiro Jamali, Mounir de la Rosette, Jean Kuroda, Shinnosuke Smith, Ryan P. Baser, Aykut Kalkanli, Arif Tadros, Nicholas N. Aydos, Kaan Mierzwa, Tiago Cesar Khalafalla, Kareim Malhotra, Vineet Moussa, Mohamad Finocchi, Federica Rachman, Rinaldo Indra Giulioni, Carlo Avidor-Reiss, Tomer Kahraman, Oguzhan Ceker, Gokhan Zenoaga-Barbarosie, Catalina Barrett, Trenton L. Yilmaz, Mehmet Kadioglu, Ates Jindal, Sunil Omran, Huda Bocu, Kadir Karthikeyan, Vilvapathy Senguttuvan Franco, Giorgio Fernando Solorzano, Jesus Vishwakarma, Ranjit B. Arianto, Eko Garrido, Nicolas Jain, Divyanu Gherabi, Nazim Sokolakis, Ioannis Palani, Ayad Calik, Gokhan Kulaksiz, Deniz Simanaviciene, Vaida Simopoulou, Mara Gungor, Nur Dokuzeylul Blecher, Gideon Falcone, Marco Jezek, Davor Preto, Mirko Amar, Edouard Le, Tan V. Ahn, Sun Tae Rezano, Andri Singh, Keerti Rocco, Lucia Savira, Missy Rajmil, Osvaldo Darbandi, Sara Sogutdelen, Emrullah Boeri, Luca Hernandez, Guadalupe Hakim, Lukman Morimoto, Yoshiharu Japari, Andrian Sofikitis, Nikolaos Altay, Baris Mahmutoglu, Asli Metin Al Hashimi, Manaf Ziouziou, Imad Anagnostopoulou, Christina Lin, Haocheng Shah, Rupin https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64315 2024-05-22T09:30:10Z 2024-01-01T00:00:00Z

Title: Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility A Global Survey, Current Guidelines, and Expert Recommendations Authors: Agarwal, Ashok; Farkouh, Ala'a; Saleh, Ramadan; Hamoda, Taha Abo-Almagd Abdel-Meguid; Salvio, Gianmaria; Boitrelle, Florence; Harraz, Ahmed M.; Abou Ghayda, Ramy; Kavoussi, Parviz; Gul, Murat; Toprak, Tuncay; Russo, Giorgio Ivan; Durairajanayagam, Damayanthi; Rambhatla, Amarnath; Birowo, Ponco; Cannarella, Rossella; Nguyen Ho Vinh Phuoc; Zini, Armand; Arafa, Mohamed; Wyns, Christine; Tremellen, Kelton; Sarikaya, Selcuk; Lewis, Sheena; Evenson, Donald P.; Ko, Edmund; Calogero, Aldo E.; Bahar, Fahmi; Martinez, Marlon; Ambar, Rafael F.; Colpi, Giovanni M.; Bakircioglu, Mustafa Emre; Henkel, Ralf; Kandil, Hussein; Serefoglu, Ege Can; Alfakhri, Abdullah; Tsujimura, Akira; Kheradmand, Alireza; Marino, Angelo; Adamyan, Aram; Zilaitiene, Birute; Ozer, Cevahir; Pescatori, Edoardo; Vogiatzi, Paraskevi; Busetto, Gian Maria; Balercia, Giancarlo; Elbardisi, Haitham; Akhavizadegan, Hamed; Sajadi, Hesamoddin; Taniguchi, Hisanori; Park, Hyun Jun; Rosas, Israel Maldonado; Al-Marhoon, Mohamed; Gilani, Mohammad Ali Sadighi; Alhathal, Naif; Nguyen Quang; Pinggera, Germar-Michael; Kothari, Priyank; Micic, Sava; Homa, Sheryl; Tran Quang Tien Long; Zohdy, Wael; Atmoko, Widi; Ibrahim, Wael; Sabbaghian, Marjan; Abumelha, Saad Mohammed; Chung, Eric; Ugur, Muhammet Rasit; Ozkent, Mehmet Serkan; Selim, Osama; Darbandi, Mahsa; Fukuhara, Shinichiro; Jamali, Mounir; de la Rosette, Jean; Kuroda, Shinnosuke; Smith, Ryan P.; Baser, Aykut; Kalkanli, Arif; Tadros, Nicholas N.; Aydos, Kaan; Mierzwa, Tiago Cesar; Khalafalla, Kareim; Malhotra, Vineet; Moussa, Mohamad; Finocchi, Federica; Rachman, Rinaldo Indra; Giulioni, Carlo; Avidor-Reiss, Tomer; Kahraman, Oguzhan; Ceker, Gokhan; Zenoaga-Barbarosie, Catalina; Barrett, Trenton L.; Yilmaz, Mehmet; Kadioglu, Ates; Jindal, Sunil; Omran, Huda; Bocu, Kadir; Karthikeyan, Vilvapathy Senguttuvan; Franco, Giorgio; Fernando Solorzano, Jesus; Vishwakarma, Ranjit B.; Arianto, Eko; Garrido, Nicolas; Jain, Divyanu; Gherabi, Nazim; Sokolakis, Ioannis; Palani, Ayad; Calik, Gokhan; Kulaksiz, Deniz; Simanaviciene, Vaida; Simopoulou, Mara; Gungor, Nur Dokuzeylul; Blecher, Gideon; Falcone, Marco; Jezek, Davor; Preto, Mirko; Amar, Edouard; Le, Tan V.; Ahn, Sun Tae; Rezano, Andri; Singh, Keerti; Rocco, Lucia; Savira, Missy; Rajmil, Osvaldo; Darbandi, Sara; Sogutdelen, Emrullah; Boeri, Luca; Hernandez, Guadalupe; Hakim, Lukman; Morimoto, Yoshiharu; Japari, Andrian; Sofikitis, Nikolaos; Altay, Baris; Mahmutoglu, Asli Metin; Al Hashimi, Manaf; Ziouziou, Imad; Anagnostopoulou, Christina; Lin, Haocheng; Shah, Rupin Abstract: Purpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the exami-nation and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. Materials and Methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current profes-sional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. Results: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuri-dine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely in-fluenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respon-dents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). Conclusions: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers en-countered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory inter-pretation of SDF testing are crucial.

2024-01-01T00:00:00Z Ahn, Sun Tae Hwang, W. Cho, S. B. Lee, H. S. Kim, J. W. Park, Hong Seok Moon, Du Geon Oh, Mi Mi https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63599 2023-12-13T11:01:41Z 20230310-01-01T00:00:00Z

Title: Do changes in metabolic health and obesity affect the incidence of urolithiasis? A nationally representative cohort study Authors: Ahn, Sun Tae; Hwang, W.; Cho, S. B.; Lee, H. S.; Kim, J. W.; Park, Hong Seok; Moon, Du Geon; Oh, Mi Mi Abstract: Introduction & Objectives Metabolic health and obesity are not stable conditions, however effect of changes in the status of these conditions on urolithiasis remains unclear. In this study, we tried to determine whether changes in metabolic health and obesity affect the incidence of urolithiasis using national health screening cohort. Materials & Methods The National Health Insurance Service-National Health Screening database was used for this study (NHIS-2022-2-156). The study cohort consisted of 514,866 health screening examinees between 2009 and 2010. Metabolic health was determined according to the modified criteria by the National Cholesterol Education Program-Adult Treatment Panel III, while obesity was determined by body mass index. Based on the results of initial (2009-2010) and second (2011-2012) health screening, the cohorts were divided according to changes in obesity and metabolic health status, after which participants were followed-up for urolithiasis from 2013 to 2020. Cox proportional hazards regression was used to determine adjusted hazard ratios (aHRs) and 95% CIs. This study was approved by Ethical Committee of the Korea University Hospital. Results Total 265,162 of examinees who contributed a total of 1,814,200 person-years of follow up were eligible for this cohort study, during which 11,641 subjects were developed urolithiasis. Groups with persistent obese and metabolically unhealthy showed highest aHRs, whereas in groups with improved obesity or metabolic health observed lower aHRs compared to persistent groups (Table 1). Conclusions We found maintaining metabolically healthy and normal weight or improving metabolic health and reducing weight may lead to decreased risk of urolithiasis development.

20230310-01-01T00:00:00Z Jo, S. B. Ahn, S. T. Hwang, W. Lee, H. S. Kim, J. W. Oh, M. M. Moon, D. G. Park, H. S. https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63597 2023-12-13T11:01:41Z 20230310-01-01T00:00:00Z

Title: Differences in the composition of urinary stone in metabolically healthy and unhealthy obese patients Authors: Jo, S. B.; Ahn, S. T.; Hwang, W.; Lee, H. S.; Kim, J. W.; Oh, M. M.; Moon, D. G.; Park, H. S. Abstract: Introduction & Objectives To investigate whether the effects of metabolic health status on stone composition were different between obese or normal weight individuals. Materials & Methods We retrospectively reviewed data of 711 patients (490 males, 221 females) with urinary stone removed between 2013 and 2020 in 2 medical centers. Normal-weight and obesity were defined as body mass index (BMI) < 25 kg/m2 and ≥ 25 kg/m2, respectively. Metabolically obese was defined as the presence of ≥3 components of metabolic syndrome. Patients were stratified into metabolically healthy, normal-weight (MHNW); metabolically obese, normal-weight (MONW); metabolically healthy, obese (MHO); metabolically obese, obese (MOO). All urinary stones were analyzed using infrared spectrophotometry and categorized according to their main component. This study was approved by Ethical Committee of the Korea University Hospital. Results Patient’s mean age was 58.6 years (range 16 – 96). Of 715 patients, 268 (37.7%) were MHNW, 102 (14.3%) were MONW, 235 (33.1%) were MHO and 106 (14.9%) were MOO. The prevalence of stone components for each group was presented in Figure 1. When we analyzed using MHNW group as a reference, the multivariable adjusted HRs (95% CIs) for uric acid stone comparing MONW, MHO and MOO groups were 3.33 (1.89–5.89, p < 0.01), 0.72 (0.40–1.29, p=0.269), and 4.49 (2.59–7.80, p < 0.01), respectively, whereas the corresponding HRs (95% CIs) for calcium oxalate stone were not significantly different between groups. Conclusions Metabolic health status was associated with higher prevalence of uric acid stone in both normal-weight and obese individuals, indicating metabolic syndrome per se as an independent risk factor for uric acid stone rather than obesity.

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