https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/383 2026-04-04T10:15:40Z 2026-04-04T10:15:40Z Chung, Eric Hui, Jiang Xin, Zhong Cheng Kim, Sae Woong Moon, Du Geon Yuan, Yiming Nagao, Koichi Hakim, Lukman Chang, Hong-Chiang Mak, Siu King Duarsa, Gede Wirya Kusuma Dai, Yutian Yao, Bing Son, Hwancheol Huang, William Lin, Haocheng Nguyen, Quang Mai, Dung Ba Tien Park, Kwangsung Lee, Joe Tantiwongse, Kavirach Sato, Yoshikazu Jiann, Bang-Ping Ho, Christopher Park, Hyun Jun https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64375 2024-12-14T02:30:29Z 2024-07-01T00:00:00Z

Title: Management of Male Infertility with Coexisting Sexual Dysfunction: A Consensus Statement and Clinical Recommendations from the Asia-Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men's Health and Aging (ASMHA) Authors: Chung, Eric; Hui, Jiang; Xin, Zhong Cheng; Kim, Sae Woong; Moon, Du Geon; Yuan, Yiming; Nagao, Koichi; Hakim, Lukman; Chang, Hong-Chiang; Mak, Siu King; Duarsa, Gede Wirya Kusuma; Dai, Yutian; Yao, Bing; Son, Hwancheol; Huang, William; Lin, Haocheng; Nguyen, Quang; Mai, Dung Ba Tien; Park, Kwangsung; Lee, Joe; Tantiwongse, Kavirach; Sato, Yoshikazu; Jiann, Bang-Ping; Ho, Christopher; Park, Hyun Jun Abstract: Male infertility (MI) and male sexual dysfunction (MSD) can often coexist together due to various interplay factors such as psychosexual, sociocultural and relationship dynamics. The presence of each form of MSD can adversely impact male reproduction and treatment strategies will need to be individualized based on patients' factors, local expertise, and geographical socioeconomic status. The Asia Pacific Society of Sexual Medicine (APSSM) and the Asian Society of Men's Health and Aging (ASMHA) aim to provide a consensus statement and practical set of clinical recommendations based on current evidence to guide clinicians in the management of MI and MSD within the Asia-Pacific (AP) region. A comprehensive, narrative review of the literature was performed to identify the various forms of MSD and their association with MI. MEDLINE and EMBASE databases were searched for the following English language articles under the following terms: "low libido", "erectile dysfunction", "ejaculatory dysfunction", "premature ejaculation", "retrograde ejaculation", "delayed ejaculation", "anejaculation", and "orgasmic dysfunction" between January 2001 to June 2022 with emphasis on published guidelines endorsed by various organizations. This APSSM consensus committee panel evaluated and provided evidence-based recommendations on MI and clinically relevant MSD areas using a modified Delphi method by the panel and specific emphasis on locoregional socioeconomic-cultural issues relevant to the AP region. While variations exist in treatment strategies for managing MI and MSD due to geographical expertise, locoregional resources, and sociocultural factors, the panel agreed that comprehensive fertility evaluation with a multidisciplinary management approach to each MSD domain is recommended. It is important to address individual MI issues with an emphasis on improving spermatogenesis and facilitating reproductive avenues while at the same time, managing various MSD conditions with evidence-based treatments. All therapeutic options should be discussed and implemented based on the patient's individual needs, beliefs and preferences while incorporating locoregional expertise and available resources.

2024-07-01T00:00:00Z Agarwal, Ashok Farkouh, Ala'a Saleh, Ramadan Hamoda, Taha Abo-Almagd Abdel-Meguid Salvio, Gianmaria Boitrelle, Florence Harraz, Ahmed M. Abou Ghayda, Ramy Kavoussi, Parviz Gul, Murat Toprak, Tuncay Russo, Giorgio Ivan Durairajanayagam, Damayanthi Rambhatla, Amarnath Birowo, Ponco Cannarella, Rossella Nguyen Ho Vinh Phuoc Zini, Armand Arafa, Mohamed Wyns, Christine Tremellen, Kelton Sarikaya, Selcuk Lewis, Sheena Evenson, Donald P. Ko, Edmund Calogero, Aldo E. Bahar, Fahmi Martinez, Marlon Ambar, Rafael F. Colpi, Giovanni M. Bakircioglu, Mustafa Emre Henkel, Ralf Kandil, Hussein Serefoglu, Ege Can Alfakhri, Abdullah Tsujimura, Akira Kheradmand, Alireza Marino, Angelo Adamyan, Aram Zilaitiene, Birute Ozer, Cevahir Pescatori, Edoardo Vogiatzi, Paraskevi Busetto, Gian Maria Balercia, Giancarlo Elbardisi, Haitham Akhavizadegan, Hamed Sajadi, Hesamoddin Taniguchi, Hisanori Park, Hyun Jun Rosas, Israel Maldonado Al-Marhoon, Mohamed Gilani, Mohammad Ali Sadighi Alhathal, Naif Nguyen Quang Pinggera, Germar-Michael Kothari, Priyank Micic, Sava Homa, Sheryl Tran Quang Tien Long Zohdy, Wael Atmoko, Widi Ibrahim, Wael Sabbaghian, Marjan Abumelha, Saad Mohammed Chung, Eric Ugur, Muhammet Rasit Ozkent, Mehmet Serkan Selim, Osama Darbandi, Mahsa Fukuhara, Shinichiro Jamali, Mounir de la Rosette, Jean Kuroda, Shinnosuke Smith, Ryan P. Baser, Aykut Kalkanli, Arif Tadros, Nicholas N. Aydos, Kaan Mierzwa, Tiago Cesar Khalafalla, Kareim Malhotra, Vineet Moussa, Mohamad Finocchi, Federica Rachman, Rinaldo Indra Giulioni, Carlo Avidor-Reiss, Tomer Kahraman, Oguzhan Ceker, Gokhan Zenoaga-Barbarosie, Catalina Barrett, Trenton L. Yilmaz, Mehmet Kadioglu, Ates Jindal, Sunil Omran, Huda Bocu, Kadir Karthikeyan, Vilvapathy Senguttuvan Franco, Giorgio Fernando Solorzano, Jesus Vishwakarma, Ranjit B. Arianto, Eko Garrido, Nicolas Jain, Divyanu Gherabi, Nazim Sokolakis, Ioannis Palani, Ayad Calik, Gokhan Kulaksiz, Deniz Simanaviciene, Vaida Simopoulou, Mara Gungor, Nur Dokuzeylul Blecher, Gideon Falcone, Marco Jezek, Davor Preto, Mirko Amar, Edouard Le, Tan V. Ahn, Sun Tae Rezano, Andri Singh, Keerti Rocco, Lucia Savira, Missy Rajmil, Osvaldo Darbandi, Sara Sogutdelen, Emrullah Boeri, Luca Hernandez, Guadalupe Hakim, Lukman Morimoto, Yoshiharu Japari, Andrian Sofikitis, Nikolaos Altay, Baris Mahmutoglu, Asli Metin Al Hashimi, Manaf Ziouziou, Imad Anagnostopoulou, Christina Lin, Haocheng Shah, Rupin https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64315 2024-05-22T09:30:10Z 2024-01-01T00:00:00Z

Title: Technical Aspects and Clinical Limitations of Sperm DNA Fragmentation Testing in Male Infertility A Global Survey, Current Guidelines, and Expert Recommendations Authors: Agarwal, Ashok; Farkouh, Ala'a; Saleh, Ramadan; Hamoda, Taha Abo-Almagd Abdel-Meguid; Salvio, Gianmaria; Boitrelle, Florence; Harraz, Ahmed M.; Abou Ghayda, Ramy; Kavoussi, Parviz; Gul, Murat; Toprak, Tuncay; Russo, Giorgio Ivan; Durairajanayagam, Damayanthi; Rambhatla, Amarnath; Birowo, Ponco; Cannarella, Rossella; Nguyen Ho Vinh Phuoc; Zini, Armand; Arafa, Mohamed; Wyns, Christine; Tremellen, Kelton; Sarikaya, Selcuk; Lewis, Sheena; Evenson, Donald P.; Ko, Edmund; Calogero, Aldo E.; Bahar, Fahmi; Martinez, Marlon; Ambar, Rafael F.; Colpi, Giovanni M.; Bakircioglu, Mustafa Emre; Henkel, Ralf; Kandil, Hussein; Serefoglu, Ege Can; Alfakhri, Abdullah; Tsujimura, Akira; Kheradmand, Alireza; Marino, Angelo; Adamyan, Aram; Zilaitiene, Birute; Ozer, Cevahir; Pescatori, Edoardo; Vogiatzi, Paraskevi; Busetto, Gian Maria; Balercia, Giancarlo; Elbardisi, Haitham; Akhavizadegan, Hamed; Sajadi, Hesamoddin; Taniguchi, Hisanori; Park, Hyun Jun; Rosas, Israel Maldonado; Al-Marhoon, Mohamed; Gilani, Mohammad Ali Sadighi; Alhathal, Naif; Nguyen Quang; Pinggera, Germar-Michael; Kothari, Priyank; Micic, Sava; Homa, Sheryl; Tran Quang Tien Long; Zohdy, Wael; Atmoko, Widi; Ibrahim, Wael; Sabbaghian, Marjan; Abumelha, Saad Mohammed; Chung, Eric; Ugur, Muhammet Rasit; Ozkent, Mehmet Serkan; Selim, Osama; Darbandi, Mahsa; Fukuhara, Shinichiro; Jamali, Mounir; de la Rosette, Jean; Kuroda, Shinnosuke; Smith, Ryan P.; Baser, Aykut; Kalkanli, Arif; Tadros, Nicholas N.; Aydos, Kaan; Mierzwa, Tiago Cesar; Khalafalla, Kareim; Malhotra, Vineet; Moussa, Mohamad; Finocchi, Federica; Rachman, Rinaldo Indra; Giulioni, Carlo; Avidor-Reiss, Tomer; Kahraman, Oguzhan; Ceker, Gokhan; Zenoaga-Barbarosie, Catalina; Barrett, Trenton L.; Yilmaz, Mehmet; Kadioglu, Ates; Jindal, Sunil; Omran, Huda; Bocu, Kadir; Karthikeyan, Vilvapathy Senguttuvan; Franco, Giorgio; Fernando Solorzano, Jesus; Vishwakarma, Ranjit B.; Arianto, Eko; Garrido, Nicolas; Jain, Divyanu; Gherabi, Nazim; Sokolakis, Ioannis; Palani, Ayad; Calik, Gokhan; Kulaksiz, Deniz; Simanaviciene, Vaida; Simopoulou, Mara; Gungor, Nur Dokuzeylul; Blecher, Gideon; Falcone, Marco; Jezek, Davor; Preto, Mirko; Amar, Edouard; Le, Tan V.; Ahn, Sun Tae; Rezano, Andri; Singh, Keerti; Rocco, Lucia; Savira, Missy; Rajmil, Osvaldo; Darbandi, Sara; Sogutdelen, Emrullah; Boeri, Luca; Hernandez, Guadalupe; Hakim, Lukman; Morimoto, Yoshiharu; Japari, Andrian; Sofikitis, Nikolaos; Altay, Baris; Mahmutoglu, Asli Metin; Al Hashimi, Manaf; Ziouziou, Imad; Anagnostopoulou, Christina; Lin, Haocheng; Shah, Rupin Abstract: Purpose: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the exami-nation and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice. Materials and Methods: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses related to the technical aspects of SDF testing, current profes-sional society guidelines, and the literature were used to generate expert recommendations via the Delphi method. Finally, challenges related to SDF that the clinicians encounter in their daily practice were captured. Results: The survey was completed by 436 reproductive clinicians. Overall, terminal deoxynucleotidyl transferase deoxyuri-dine triphosphate Nick-End Labeling (TUNEL) is the most commonly used assay chosen by 28.6%, followed by the sperm chromatin structure assay (24.1%), and the sperm chromatin dispersion (19.1%). The choice of the assay was largely in-fluenced by availability (70% of respondents). A threshold of 30% was the most selected cut-off value for elevated SDF by 33.7% of clinicians. Of respondents, 53.6% recommend SDF testing after 3 to 5 days of abstinence. Although 75.3% believe SDF testing can provide an explanation for many unknown causes of infertility, the main limiting factors selected by respon-dents are a lack of professional society guideline recommendations (62.7%) and an absence of globally accepted references for SDF interpretation (50.3%). Conclusions: This study represents the largest global survey on the technical aspects of SDF testing as well as the barriers en-countered by clinicians. Unified global recommendations regarding clinician implementation and standard laboratory inter-pretation of SDF testing are crucial.

2024-01-01T00:00:00Z Song, Sang Hun Lee, Jaewon Ko, Young Hwii Kim, Jong Wook Il Jung, Seung Kang, Seok Ho Park, Jinsung Seo, Ho Kyung Kim, Hyung Joon Jeong, Byong Chang Kim, Tae-Hwan Choi, Se Young Nam, Jong Kil Ku, Ja Yoon Joo, Kwan Joong Jang, Won Sik Yoon, Young Eun Yun, Seok Joong Hong, Sung-Hoo Oh, Jong Jin https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64370 2024-07-11T11:00:53Z 2023-10-01T00:00:00Z

Title: TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort Authors: Song, Sang Hun; Lee, Jaewon; Ko, Young Hwii; Kim, Jong Wook; Il Jung, Seung; Kang, Seok Ho; Park, Jinsung; Seo, Ho Kyung; Kim, Hyung Joon; Jeong, Byong Chang; Kim, Tae-Hwan; Choi, Se Young; Nam, Jong Kil; Ku, Ja Yoon; Joo, Kwan Joong; Jang, Won Sik; Yoon, Young Eun; Yun, Seok Joong; Hong, Sung-Hoo; Oh, Jong Jin Abstract: Purpose Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses. Materials and Methods Total 203 UraC patients from a multicenter database and 373 UroBC patients in single institution from 2000 to 2018 were enrolled (median follow-up, 32 months). Sheldon stage conversion to corresponding TNM staging for UraC was con-ducted for head-to-head comparison to UroBC. Perioperative clinical variables and pathological results were recorded. Stage-matched analyses for survival by stage were conducted. Results UraC patients were younger (mean age, 54 vs. 67 years; p < 0.001), with 163 patients (80.3%) receiving partial cystectomy and 23 patients (11.3%) radical cystectomy. UraC was more likely to harbor <greater than or equal to> pT3a tumors (78.8% vs. 41.8%). While 5-year recurrence-free survival, cancer-specific survival (CSS) and overall survival were comparable between two groups (63.4%, 67%, and 62.1% in UraC and 61.5%, 75.9%, and 67.8% in UroBC, respectively), generally favorable prognosis for UraC in lower stages (pT1-2) but unfavorable outcomes in higher stages (pT4) compared to UroBC was observed, although only 5-year CSS in >= pT4 showed statistical significance (p=0.028). Body mass index (hazard ratio [HR], 0.929), diabetes mellitus (HR, 1.921), pathologic T category (HR, 3.846), and lymphovascular invasion (HR, 1.993) were predictors of CSS for all patients. Conclusion Despite differing histology, UraC has comparable prognosis to UroBC with relatively favorable outcome in low stages but worse prognosis in higher stages. The presented system may be useful for future grading and risk stratification of UraC.

2023-10-01T00:00:00Z Shin, Dongho Jeon, Seung Hwan Piao, Junjie Park, Hyo Jung Tian, Wen Jie Moon, Du Geon Ahn, Sun Tae Jeon, Kyung-Hwa Zhu, Guan Qun Park, Ilbum Park, Hyun-Je Bae, Woong Jin Cho, Hyuk Jin Hong, Sung-Hoo Kim, Sae Woong https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62308 2025-01-13T12:30:45Z 2023-07-01T00:00:00Z

Title: Efficacy and Safety of Maca (Lepidium meyenii) in Patients with Symptoms of Late-Onset Hypogonadism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Authors: Shin, Dongho; Jeon, Seung Hwan; Piao, Junjie; Park, Hyo Jung; Tian, Wen Jie; Moon, Du Geon; Ahn, Sun Tae; Jeon, Kyung-Hwa; Zhu, Guan Qun; Park, Ilbum; Park, Hyun-Je; Bae, Woong Jin; Cho, Hyuk Jin; Hong, Sung-Hoo; Kim, Sae Woong Abstract: Purpose To evaluated the efficacy and safety of gelatinized Maca (Lepidium meyenii) for eugonadal patients with late onset hypogonadism symptoms (LOH). Materials and Methods Participants were instructed to receive 1,000 mg of Maca or placebo, two pills at a time, three times per day for 12 weeks before food intake. To evaluate the efficacy of the drug, Aging Males' Symptoms scale (AMS), Andro -gen Deficiency in the Aging Males (ADAM), International Prostate Symptom Score (IPSS), and International Index of Erectile Function (IIEF) questionnaires, serologic tests (total testosterone and free testosterone, total cholesterol, high density lipopro-tein cholesterol, low density lipoprotein cholesterol, triglyceride), body weight, and waist circumference were assessed at 4 and 12 weeks after treatment. Results A total of 80 participants were enrolled and randomly assigned to Maca treated group (n=41) or the placebo group (n=39). AMS, IIEF, and IPSS were significantly (p<0.05) improved in Maca treated group than in the placebo group. ADAM positive rate was also significantly (p<0.0001) decreased in Maca treated group. Conclusions Maca may be considered an effective and safe treatment for eugonadal patients with late onset hypogonadism symptoms.

2023-07-01T00:00:00Z