https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/451 2025-12-26T03:42:49Z 2025-12-26T03:42:49Z Her, Ae-Young Choi, Byoung Geol Park, Soohyung Hyun, Su Jin Choi, Cheol Ung Rha, Seung-Woon Kim, Yong Hoon Jeong, Myung Ho https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/78555 2025-10-29T05:00:10Z 2025-10-01T00:00:00Z

Title: High-intensity statin on 3-year clinical outcomes in elderly acute myocardial infarction patients underwent percutaneous coronary intervention with drug-eluting stents Authors: Her, Ae-Young; Choi, Byoung Geol; Park, Soohyung; Hyun, Su Jin; Choi, Cheol Ung; Rha, Seung-Woon; Kim, Yong Hoon; Jeong, Myung Ho Abstract: There is limited data on high-intensity statin for secondary prevention in elderly acute myocardial infarction (AMI) patients above 75 years. This study aimed to assess the impact of high-intensity statin on 3-year outcomes in elderly AMI patients (> 75 years) who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES). From the Korea AMI registry (KAMIR)-National Institutes of Health (NIH), 2,063 elderly patients were divided into three groups based on statin therapy at discharge: high-intensity statin group (n = 521), low/moderate-intensity statin group (n = 1,419), and no statin group (n = 123). The primary endpoint was the 3-year composite of cardiac death and recurrent myocardial infarction (MI). The high-intensity statin group had a similar primary endpoint incidence compared to the low/moderate-intensity statin group (11.5% vs. 12.5%; aHR: 1.053; 95% CI: 0.780-1.423; P = 0.739), but a significantly lower incidence compared to the no statin group (11.5% vs. 22.0%; aHR: 2.433; 95% CI: 1.377-4.298; P = 0.002). Major adverse cardiac events were lower in the high-intensity statin group compared to the no statin group but similar to the low/moderate-intensity statin group. High-intensity statin significantly reduced 3-year outcomes in elderly AMI patients after PCI compared to no statin, with similar benefits to low/moderate-intensity statin.

2025-10-01T00:00:00Z Ahn, Woo Jin Rha, Seung-Woon Choi, Byoung Geol Choi, Se Yeon Byun, Jae Kyeong Lee, Youjin Chesario, Manda Satria Susanti, Melly Chu, Wonsang Lee, Jieun Park, Soohyung Park, Eun Jin Kang, Dong Oh Choi, Cheol Ung Park, Chang Gyu Oh, Dong Joo https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/78451 2025-11-12T01:00:28Z 2025-10-01T00:00:00Z

Title: Long-term clinical outcomes according to first responsive dose of acetylcholine in patients with coronary artery spasm Authors: Ahn, Woo Jin; Rha, Seung-Woon; Choi, Byoung Geol; Choi, Se Yeon; Byun, Jae Kyeong; Lee, Youjin; Chesario, Manda Satria; Susanti, Melly; Chu, Wonsang; Lee, Jieun; Park, Soohyung; Park, Eun Jin; Kang, Dong Oh; Choi, Cheol Ung; Park, Chang Gyu; Oh, Dong Joo Abstract: Background: Coronary artery spasm (CAS) has become a focus of recent prognostic studies. However, research evaluating prognosis based on the initial dose of acetylcholine (ACH) at which patients first respond is lacking. This study aims to investigate long-term clinical outcomes according to the first responsive dose of ACH in patients with CAS. Methods: A total of 3783 patients with positive intracoronary provocation testing with ACH were categorized into three groups based on the dose at which they first exhibited a positive spasm response: A1 (20 mu g), A2 (50 mu g), and A3 (100 mu g). The primary endpoint was major adverse cardiovascular events (MACE), and secondary endpoints included major adverse cardiovascular and cerebrovascular events (MACCE1) and MACCE1 with recurrent angina (MACCE2). Kaplan-Meier survival analysis and multivariate Cox regression were used to assess the relationship between the initial responsive dose and the clinical outcomes up to 10 years. Results: The prevalence of coronary artery stenosis was greater in the A1 group (61.6 %) compared to the A2 group (61.1 %) and the A3 group (56.8 %). The A1 group showed a higher incidence of MACE (10.8 %) compared to the A2 group (3.7 %) and the A3 group (3.5 %, P = 0.003). MACCE2 was also more frequent in the A1 group (38.2 %) than in the A2 group (28.9 %) and the A3 group (26.4 %, P = 0.036). Consistently, in multivariable Cox regression, the A1 group demonstrated a higher risk of both MACE (HR 2.43, 95 % CI 1.01-5.81, P = 0.047) and MACCE2 (HR 1.62, 95 % CI 1.09-2.39, P = 0.016) compared to the A3 group. Conclusion: The initial responsive dose of ACH is a potential predictor of long-term clinical outcomes in patients with CAS. Patients who respond at lower doses may have a higher risk of adverse events, indicating the need for tailored therapeutic strategies based on ACH responsiveness.

2025-10-01T00:00:00Z Park, Soohyung Rha, Seung-Woon Choi, Byoung Geol Park, Sang Ho Seo, Jae-Bin Baek, Ju Yeol Choi, Jae Woong Kim, Yong Hoon Ahn, Ji-Hun Chang Kim, Gi Kim, Weon Kim, Soo-Han Sinurat, Markz Rmp Choi, Se Yeon Cha, Jin Ah Hyun, Soo Jin Choi, Cheol Ung Park, Chang Gyu https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/74461 2025-09-08T10:01:52Z 2025-07-01T00:00:00Z

Title: Efficacy and Safety of Polymer-Free Biolimus-eluting Stents versus Durable Polymer Novolimus-eluting Stents in a Real-World Clinical Practice (FREEDOM-DES Trial) Authors: Park, Soohyung; Rha, Seung-Woon; Choi, Byoung Geol; Park, Sang Ho; Seo, Jae-Bin; Baek, Ju Yeol; Choi, Jae Woong; Kim, Yong Hoon; Ahn, Ji-Hun; Chang Kim, Gi; Kim, Weon; Kim, Soo-Han; Sinurat, Markz Rmp; Choi, Se Yeon; Cha, Jin Ah; Hyun, Soo Jin; Choi, Cheol Ung; Park, Chang Gyu

2025-07-01T00:00:00Z Park, Tae Shik Ahn, Woo Jin Rha, Seung-Woon Choi, Se Yeon Cha, Jinah Hyun, Sujin Sinurat, Markz Rmp Park, Soohyung Choi, Cheol Ung Park, Chang Gyu Oh, Dong Joo Choi, Byoung Geol https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/75717 2025-07-10T02:15:33Z 2025-06-01T00:00:00Z

Title: Coronary vasomotor response incidence to intracoronary acetylcholine provocation test according to the severity of insignificant coronary artery stenosis in Korean population Authors: Park, Tae Shik; Ahn, Woo Jin; Rha, Seung-Woon; Choi, Se Yeon; Cha, Jinah; Hyun, Sujin; Sinurat, Markz Rmp; Park, Soohyung; Choi, Cheol Ung; Park, Chang Gyu; Oh, Dong Joo; Choi, Byoung Geol Abstract: BACKGROUND: Coronary artery spasm (CAS) is a cause of variant angina. However, the understanding of CAS patterns in the presence of mild-to-moderate coronary artery stenosis is limited. This study aimed to evaluate the incidence and patterns of CAS in patients with insignificant coronary artery stenosis using intracoronary acetylcholine (ACH) provocation test. METHODS: In this study, 6513 patients without significant coronary artery stenosis who underwent intracoronary ACH provocation test were enrolled. Patients were divided into three groups, based on the severity of coronary artery stenosis: the non group (stenosis <30%, n = 2833), the mild group (30-49%, n = 3278) and the moderate group (50-69%, n = 402). Vasomotor responses were observed among three different groups. RESULTS: The baseline characteristics of the patients in the mild and moderate groups were worse than in the non group. They were older, had higher prevalence of hypertension, diabetes, dyslipidemia, and smoking habit. During the ACH test, CAS was observed in 58.1% of the overall population. The mild group (60.1%) and the moderate group (60.9%) showed a higher incidence than the non group (55.3%, P < 0.001). In addition, among cases of CAS, the mild group (3.2%) and the moderate group (8.5%) responded more at a lowest dose of ACH than the non group (3.1%, P < 0.001). CONCLUSIONS: In patients with chest pain without significant coronary artery stenosis, CAS was observed in over half of the cases. Furthermore, CAS was found to be more frequent and more susceptible in patients with mild-to-moderate coronary artery stenosis compared with those without fixed stenosis. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

2025-06-01T00:00:00Z