https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/84 2026-04-04T09:36:22Z 2026-04-04T09:36:22Z Jeong, Tae Yeong Lim, Soo-Yeon Seong, Je Kyung Kim, Kyoungmi https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/77982 2025-10-16T01:30:40Z 2023-01-01T00:00:00Z

Title: Base Editors-Methods and Protocols Authors: Jeong, Tae Yeong; Lim, Soo-Yeon; Seong, Je Kyung; Kim, Kyoungmi Abstract: Base editors, such as cytosine and adenine base editors, are composed of nickase Cas9 (nCas9) and deaminase and serve as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based enzymatic tools for specific nucleotide substitutions. They are mainly the most effective genome editing tools for introducing point mutations, such as C-to-T and A-to-G conversions. The enhanced base editor, a C-to-G base editor (CGBE), can perform other nucleotide substitutions, such as C-to-G conversions. Here, we introduce a method for generating mouse models with point mutations using a base editing system. © 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

2023-01-01T00:00:00Z Park, Eui Ho Han, Hee Chul https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62168 2024-09-11T09:30:07Z 2021-11-01T00:00:00Z

Title: Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs) Authors: Park, Eui Ho; Han, Hee Chul Abstract: Pain perception serves to protect living organism against an actual or potential tissue damage. Glutamatergic signaling of nervous system plays a crucial role in initiating and maintaining pain. It is important to note that the glutamatergic signaling in peripheral nervous system (PNS) is responsible for the first phase of pain processing. Recent animal studies support that some types of glutamate receptors such as NMDA receptor and group I metabotropic glutamate receptors (mGluRs) in cell bodies and primary afferent fibers of PNS can potentiate the nociceptive processing. However, much interest was less present in the role of peripheral group III mGluRs for regulating pain. Therefore, the present review will focus on peripheral group III mGluRs of PNS that can offer a better understanding of inhibitory role and therapeutic potential in pain processing.

2021-11-01T00:00:00Z 한희철 https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/44338 2023-12-13T03:01:41Z 2019-03-01T00:00:00Z

Title: (한눈에 알 수 있는) 생리학 Authors: 한희철

2019-03-01T00:00:00Z 한희철 https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/44337 2023-12-13T03:01:41Z 2019-03-01T00:00:00Z

Title: (Berne & Levy) 생리학 Authors: 한희철

2019-03-01T00:00:00Z