https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/160 2025-12-30T13:30:05Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62886 Title: Oral care and survival time in terminally ill patients with cancer: nested case- control pilot study Authors: Choi, Youn Seon; Lee, Yoo Jeong; Hwang, In Cheol; Ahn, Hong Yup Abstract: [No abstract available] 2024-11-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64305 Title: Association Between Premature Menopause and Cardiovascular Diseases and All‐Cause Mortality in Korean Women Authors: Lee, Gyu Bae; Nam, Ga Eun; Kim, Wonsock; Han, Byoungduck; Cho, Kyung Hwan; Kim, Seon Mee; Choi, Youn Seon; Kim, Do Hoon; Park, Yong‐Gyu; Jung, Jin‐Hyung; Han, Kyungdo; Kim, Yang‐Hyun Abstract: Background Mortality from cardiovascular diseases in Asian populations is considerable. Menopause is a risk‐enhancing factor for cardiovascular disease, but it is unclear whether menopause is an independent risk factor for cardiovascular disease and mortality in Asian women. Methods and Results A total of 1 159 405 postmenopausal women, who had participated in the health examinations of the Korean National Health Insurance Service in 2009, were analyzed, and their reproductive histories were taken. A multivariable Cox proportional hazard model assessed the hazard ratios (HRs) of myocardial infarction (MI), ischemic stroke, and all‐cause mortality, according to the history of premature menopause and age at menopause. After an average 10‐year follow‐up, there were 31 606, 45 052, and 77 680 new cases of MI, ischemic stroke, and all‐cause mortality, respectively. The women with premature menopause exhibited increased risks of MI (HR, 1.40 [95% CI, 1.31–1.50]), ischemic stroke (HR, 1.24 [95% CI, 1.17–1.31]), and all‐cause mortality (HR, 1.19 [95% CI, 1.14–1.24]) when compared with women with menopause aged ≥50 years. The highest risk was evident with menopause between the ages of 30 and 34 years (HR for MI, 1.52 [95% CI, 1.30–1.78]; HR for ischemic stroke, 1.29 [95% CI, 1.12–1.48]; HR for all‐cause mortality, 1.33 [95% CI, 1.20–1.47]) when compared with women with menopause aged ≥50 years. Conclusions Earlier age at menopause was associated with increased risks for MI, ischemic stroke, and all‐cause mortality. Future guidelines and risk assessment tools should consider menopause as an independent risk factor of cardiovascular disease in Korean women. 2023-11-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62538 Title: Association Between Smoking Cessation and the Risk of Cholangiocarcinoma and Ampulla of Vater Cancer: A Nationwide Cohort Study Authors: Park, Joo-Hyun; Hong, Jung Yong; Han, Kyungdo Abstract: Introduction The association between smoking cessation and intrahepatic and extrahepatic cholangiocarcinoma (iCCA and eCCA) risk is unclear. Furthermore, the association in individuals with preexisting risk factors is unknown. We aimed to investigate the association between smoking status (especially smoking cessation) and CCA risk according to individuals' glycemic status. Methods In this nationwide cohort study, 9,520,629 adults without cancer who underwent national health screening by the Korean National Health Insurance Service in 2009 were followed up through 2018. The hazard ratios (HRs) and 95% confidence intervals (CIs) for CCA were estimated after adjusting for potential confounders. Results During the 78.3 person-years of follow-up, 16,236 individuals were newly diagnosed with CCA. Quitters had a significantly lower risk of iCCA and eCCA compared to current smokers in all glycemic status groups (all P<0.01). The HRs (95% CIs) for iCCA in current smokers and quitters were 1.33 (1.24-1.43) vs. 0.98 (0.90-1.06) in individuals with normoglycemia, 1.49 (1.37-1.63) vs. 1.17 (1.06-1.28) in individuals with prediabetes, and 2.15 (1.96-2.37) vs. 1.58 (1.42-1.75) in individuals with diabetes, compared to never-smokers with normoglycemia. Current smokers with diabetes or prediabetes had a synergistically increased risk of iCCA (all P<0.01). However, quitters with diabetes and prediabetes had an iCCA risk comparable to that of never-smokers. Analysis of eCCA yielded similar results. Smoking was not independently associated with the risk of the ampulla of Vater cancer. However, smoking combined with diabetes or prediabetes was associated with an increased risk of the ampulla of Vater cancer (all P<0.05). Discussion/Conclusion Smoking cessation was associated with a reduced risk of CCA, despite the synergistically increased risk in current smokers with diabetes and prediabetes. Our findings suggest a crucial opportunity to reduce the risk of CCA. More individualized and intensive cancer prevention education is needed against CCA. 2023-10-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63957 Title: Bone Mineral Density and the Risk of Parkinson's Disease in Postmenopausal Women Authors: Park, Kye-Yeung; Jung, Jin-Hyung; Hwang, Hwan-Sik; Park, Hoon-Ki; Han, Kyungdo; Nam, Ga Eun Abstract: BackgroundWhether bone mineral density (BMD) is related to the risk of Parkinson's disease (PD) is unclear. ObjectivesThe objective of this study was to examine the association between BMD status and incident PD in postmenopausal women. MethodsWe retrospectively examined a nationwide cohort of 272,604 women aged 66 years who participated in the 2009-2012 Korean national health screening for transitional ages. BMD was evaluated using dual-energy X-ray absorptiometry of the central bones. The use of antiosteoporosis medications (AOMs) was assessed. We performed multivariable Cox proportional hazards regression to evaluate the association between BMD and PD risk by calculating hazard ratios (HRs) and 95% confidence intervals (CIs). ResultsDuring the median follow-up of 7.7 years, 2,884 (1.1%) incident PD cases developed. After adjusting for confounding factors, lower BMD was associated with an increased risk of PD (P for trend <0.001). Individuals with osteoporosis had a 1.40-fold higher HR (1.40, 95% CI: 1.25-1.56) than those with a normal BMD. Sensitivity analyses suggested the associations robust to longer lag periods and further adjustment. These associations were prominent in individuals without AOM use before or after enrollment (P for interaction = 0.031 and 0.014). Increased risks of PD in individuals with osteopenia and osteoporosis who did not use AOMs were attenuated by the medication use during the follow-up period, regardless of previous AOM use. ConclusionsLower postmenopausal BMD and osteoporosis were associated with an increased risk of PD. In addition, this association could be mitigated using AOMs. Proper management of BMD in postmenopausal women may help prevent PD. & COPY; 2023 International Parkinson and Movement Disorder Society. 2023-09-01T00:00:00Z