https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/413 2026-04-04T08:36:15Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/78333 Title: Maternal Faecalibacterium pathobionts and low-fiber diets synergize to impact offspring health: implications for atopic dermatitis Authors: Lee, Dongju; Park, Jongwook; Park, Song-Yi; Hwang, Junghyun; Kim, Sewon; Kee, Sun-Ho; Kim, Heenam Stanley Abstract: BackgroundThe incidence of atopic dermatitis (AD) has increased globally in recent decades. A recent study identified enrichment of Faecalibacterium subspecies in young AD patients, implicating these gut bacteria in disease pathogenesis. This was unexpected, as Faecalibacterium is widely recognized as one of the most beneficial bacteria in the human gut.ResultsWe tested the bacteria in female mice and observed their effect on the gut microbiome and overall health, which subsequently influenced the health of their offspring. These effects were markedly exacerbated when female mice were fed a low-fiber diet, leading to heightened systemic inflammation, skin damage, and hair loss in their offspring. Offspring of female mice receiving a low-fiber diet without pathobiont administration exhibited reduced symptom severity, which was further mitigated bythe administration of the beneficial strain A2-165.ConclusionsThese findings provide compelling evidence that maternalFaecalibacterium pathobionts play a critical role in the development of systemic conditions in offspring, offering valuable insights into the etiology of AD. Furthermore, the synergistic effect of gut microbiota dysbiosis and low fiber intake highlights the potential impact of modern dietary trends on the rising prevalence of AD and other chronic conditions.72XxYzMNRBDBX66hhLLuNvVideo AbstractConclusionsThese findings provide compelling evidence that maternalFaecalibacterium pathobionts play a critical role in the development of systemic conditions in offspring, offering valuable insights into the etiology of AD. Furthermore, the synergistic effect of gut microbiota dysbiosis and low fiber intake highlights the potential impact of modern dietary trends on the rising prevalence of AD and other chronic conditions.72XxYzMNRBDBX66hhLLuNvVideo Abstract 2025-08-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65309 Title: Comparison between a laser-lancing device and automatic incision lancet for capillary blood sampling from the heel of newborn infants: a randomized feasibility trial Authors: Yun, Chul Kyu; Choi, Eui Kyung; Kim, Hyung Jin; Kim, Jaeyoung; Park, Byung Cheol; Park, Kyuhee; Choi, Byung Min Abstract: No abstract available 2024-08-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65765 Title: Investigating neuromodulatory effect of transauricular vagus nerve stimulation on resting-state electroencephalography Authors: Lee, Yun-Sung; Kim, Woo-Jin; Shim, Miseon; Hong, Ki Hwan; Choi, Hyuk; Song, Jae-Jun; Hwang, Han-Jeong Abstract: Purpose: The purpose of this study was to investigate the neuromodulatory effects of transauricular vagus nerve stimulation (taVNS) and determine optimal taVNS duration to induce the meaningful neuromodulatroty effects using resting-state electroencephalography (EEG). Method: Fifteen participants participated in this study and taVNS was applied to the cymba conchae for a duration of 40 min. Resting-state EEG was measured before and during taVNS application. EEG power spectral density (PSD) and brain network indices (clustering coefficient and path length) were calculated across five frequency bands (delta, theta, alpha, beta and gamma), respectively, to assess the neuromodulatory effect of taVNS. Moreover, we divided the whole brain region into the five regions of interest (frontal, central, left temporal, right temporal, and occipital) to confirm the neuromodulation effect on each specific brain region. Result: Our results demonstrated a significant increase in EEG frequency powers across all five frequency bands during taVNS. Furthermore, significant changes in network indices were observed in the theta and gamma bands compared to the pre-taVNS measurements. These effects were particularly pronounced after approximately 10 min of stimulation, with a more dominant impact observed after approximately 20-30 min of taVNS application. Conclusion: The findings of this study indicate that taVNS can effectively modulate the brain activity, thereby exerting significant effects on brain characteristics. Moreover, taVNS duration of approximately 20-30 min was considered appropriate for inducing a stable and efficient neuromodulatory effects. Consequently, these findings have the potential to contribute to research aimed at enhancing cognitive and motor functions through the modulation of EEG using taVNS. 2024-07-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65114 Title: Dissolution of ribonucleoprotein condensates by the embryonic stem cell protein L1TD1 Authors: Jin, Sang Woo; Seong, Youngmo; Yoon, Dayoung; Kwon, Young-Soo; Song, Hoseok Abstract: L1TD1 is a cytoplasmic RNA-binding protein specifically expressed in pluripotent stem cells and, unlike its mouse ortholog, is essential for the maintenance of stemness in human cells. Although L1TD1 is the only known protein-coding gene domesticated from a LINE-1 (L1) retroelement, the functional legacy of its ancestral protein, ORF1p of L1, and how it is manifested in L1TD1 are still unknown. Here, we determined RNAs associated with L1TD1 and found that, like ORF1p, L1TD1 binds L1 RNAs and localizes to high-density ribonucleoprotein (RNP) condensates. Unexpectedly, L1TD1 enhanced the translation of a subset of mRNAs enriched in the condensates. L1TD1 depletion promoted the formation of stress granules in embryonic stem cells. In HeLa cells, ectopically expressed L1TD1 facilitated the dissolution of stress granules and granules formed by pathological mutations of TDP-43 and FUS. The glutamate-rich domain and the ORF1-homology domain of L1TD1 facilitated dispersal of the RNPs and induced autophagy, respectively. These results provide insights into how L1TD1 regulates gene expression in pluripotent stem cells. We propose that the ability of L1TD1 to dissolve stress granules may provide novel opportunities for treatment of neurodegenerative diseases caused by disturbed stress granule dynamics. Graphical Abstract 2024-04-01T00:00:00Z