ScholarWorks@Korea University College of Medicine
http://scholarworks.korea.ac.kr:80/kumedicine
The ScholarWorks digital repository system captures, stores, indexes, preserves, and distributes digital research material.2024-03-19T00:44:08ZA Phase 3 randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability and immunogenicity of a 21-valent PCV, V116, in pneumococcal vaccine-naive adults (STRIDE-3)
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65335
Title: A Phase 3 randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability and immunogenicity of a 21-valent PCV, V116, in pneumococcal vaccine-naive adults (STRIDE-3)
Authors: Bruno, Christopher; Buntinx, Erik; Pelayo, Enrique; Kamerbeek, Jackie M.; Garcia-Huidobro, Diego; Barranco-Santana, Elizabeth A.; Sjoberg, Folke; Song, Joon Young; Greenberg, David; Grijalva, Carlos G.; Orenstein, Walter A.; Morgan, Leslie; Fernsler, Doreen; Xu, Weifeng; Waleed, Muhammad; Li, Jianing; Buchwald, Ulrike K.; Platt, Heather L.202401-01-01T00:00:00ZCANCER LETTERS 581 (2024) 216528 216546 PRECISION CANCER MEDICINE IN OVARIAN CANCER
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65458
Title: CANCER LETTERS 581 (2024) 216528 216546 PRECISION CANCER MEDICINE IN OVARIAN CANCER
Authors: Kim, Se Ik; Jo, HyunA.; Kim, Heeyeon; Lee, Juwon; Cho, Untack; Kim, Soochi; Kim, Boyun; Seol, Aeran; Lee, Maria; Lee, Cheol; Ahn, Taejin; Song, Yong Sang202401-01-01T00:00:00ZIntracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65365
Title: Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution
Authors: Jeong, Jaekwang; Lee, Jongwon; Talaia, Gabriel; Kim, Wonnam; Song, Junho; Hong, Juhyeon; Yoo, Kwangmin; Gonzalez, David G.; Athonvarangkul, Diana; Shin, Jaehun; Dann, Pamela; Haberman, Ann M.; Kim, Lark Kyun; Ferguson, Shawn M.; Choi, Jungmin; Wysolmerski, John
Abstract: Involution of the mammary gland after lactation is a dramatic example of coordinated cell death. Weaning causes distension of the alveolar structures due to the accumulation of milk, which, in turn, activates STAT3 and initiates a caspase-independent but lysosome-dependent cell death (LDCD) pathway. Although the importance of STAT3 and LDCD in early mammary involution is well established, it has not been entirely clear how milk stasis activates STAT3. In this report, we demonstrate that protein levels of the PMCA2 calcium pump are significantly downregulated within 2-4 h of experimental milk stasis. Reductions in PMCA2 expression correlate with an increase in cytoplasmic calcium in vivo as measured by multiphoton intravital imaging of GCaMP6f fluorescence. These events occur concomitant with the appearance of nuclear pSTAT3 expression but prior to significant activation of LDCD or its previously implicated mediators such as LIF, IL6, and TGF beta 3, all of which appear to be upregulated by increased intracellular calcium. We further demonstrate that increased intracellular calcium activates STAT3 by inducing degradation of its negative regulator, SOCS3. We also observed that milk stasis, loss of PMCA2 expression and increased intracellular calcium levels activate TFEB, an important regulator of lysosome biogenesis through a process involving inhibition of CDK4/6 and cell cycle progression. In summary, these data suggest that intracellular calcium serves as an important proximal biochemical signal linking milk stasis to STAT3 activation, increased lysosomal biogenesis, and lysosome-mediated cell death.2024-12-01T00:00:00ZT2 Black Synovitis in Musculoskeletal MRI: Disease Spectrum and Imaging Characteristics of Joint Diseases
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64360
Title: T2 Black Synovitis in Musculoskeletal MRI: Disease Spectrum and Imaging Characteristics of Joint Diseases
Authors: Kang, Woo Young; Hong, Suk-Joo; Woo, Ok Hee; Kang, Chang Ho; Ahn, Kyung-Sik; Kim, Baek Hyun; Shim, Euddeum
Abstract: The synovium may be affected by a wide spectrum of disorders, including inflammatory, infectious, degenerative, traumatic, hemorrhagic, and tumorous conditions. Magnetic resonance imaging (MRI) is a valuable imaging modality to characterize synovial disorders. Most abnormal lesions appear as areas of nonspecific high signal intensity on T2-weighted images (T2-WI) due to high water content or increased perfusion. However, T2 hypointensity can be attributed to blood components of varying ages, calcification, inorganic crystals, fibrosis, caseous necrosis and/or amyloid deposition. Hypointense lesions on T2-WI are infrequent and additional clinical and imaging characteristics can help to limit the list of differential diagnoses, which may include tenosynovial giant cell tumor, synovial chondromatosis, rheumatoid arthritis, tuberculous arthritis, chronic tophaceous gout, amyloid arthropathy, synovial hemangioma, lipoma arborescens and hemosiderotic synovitis. Recently, susceptibility weighted imaging has been developed and may contribute to more accurate diagnosis for deoxygenated blood and calcium. We review the MRI features of hypointense synovial lesions on MRI and emphasize the characteristic findings that suggest a correct diagnosis.2024-06-01T00:00:00Z