https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/142 Sun, 05 Apr 2026 15:19:40 GMT 2026-04-05T15:19:40Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64065 Title: Three-dimensional imaging and quantification of epidermal innervation in atopic dermatitis Authors: Kim, D.; Lee, S.; Seo, S.; Ahn, H.; Sun, W.; Kim, B.; Rhyu, I. Abstract: Understanding the structural alteration of epidermal innervation is essential for a deeper understanding of neurogenic inflammation and pruritus in atopic dermatitis. The skin of atopic dermatitis patients has been reported to show controversial results, higher or lower intraepidermal nerve fiber densities (IENFDs). Therefore, this study was intended to verify the genuine structural alteration of epidermal innervation in atopic dermatitis through the skin-clearing technique and related three-dimensional (3-D) image quantification process as previously reported. A total of 10 (five healthy and five atopic dermatitis subjects) participants were prospectively enrolled. All subjects were male, 20s, and received biopsy/suction blister on a similar anatomical site, proximal forearm, to control other variables which could affect the results of IENFDs. The atopic dermatitis patients displayed significantly decreased intraepidermal nerve fibers, nodes, end, total length, total volume, and complexity compared with the results of healthy subjects. Furthermore, the arborizing intermingled structures of healthy subjects represented by nodes and complexity seemed to be more vividly simplified in the atopic dermatitis patients compared with the degree of decrease of well-known parameters, number of nerve fibers, or total length. In conclusion, our study successfully demonstrated the difference of 3-D whole structural images of epidermal innervation between healthy subjects and atopic dermatitis patients. Further studies with a larger number of participants are expected to show the possible relationship among structural alteration of epidermal innervation, neurosensory symptoms, and neurogenic inflammation of atopic dermatitis. Sun, 01 Jan 202305 00:00:00 GMT https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64065 202305-01-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63882 Title: Pigmented contact dermatitis and hair dyes: A retrospective case-control multicentre study in Korea Authors: Kim, Myoung Shin; Chung, Bo Young; Chang, Sung Eun; Oh, Sang Ho; Ryu, Hwa Jung; Kim, Dong Hyun; Lee, June Hyunkyung; Ko, Joo Yeon; Kim, Jeong Eun; Lee, Jong Hee; Lee, Ga Young; Jeon, Jiehyun; Choi, Hoon; Roh, Mi Ryung; Bae, Jung Min; Na, Jung-Im; Jung, Hye Jung; Bang, Chul Hwan; Kim, Hei Sung; Lee, Seung Ho; Shin, Min Kyung; Lee, Si-Hyung; Park, Kui Young; Park, Chul-Jong; Choi, Mira; Yoon, Tae-Jin; Suh, Kee Suck; Park, Young Lip; Ryoo, Young Wook; Kim, Myung Hwa; Kim, You Chan Abstract: BackgroundPigmented contact dermatitis (PCD), a rare variant of non-eczematous contact dermatitis, is clinically characterized by sudden-onset brown or grey pigmentation on the face and neck. It is hypothesized to be caused by repeated contact with low levels of allergens. ObjectivesThis study evaluated the risk of using hair dyes in patients with PCD in Korea. MethodsA total of 1033 PCD patients and 1366 controls from 31 university hospitals were retrospectively recruited. We collected and analysed the data from the patient group, diagnosed through typical clinical findings of PCD and the control group, which comprised age/sex-matched patients who visited the participating hospitals with pre-existing skin diseases other than current allergic disease or PCD. ResultsMelasma and photosensitivity were significantly more common in the control group, and a history of contact dermatitis was more common in the PCD group. There were significantly more Fitzpatrick skin type V participants in the PCD group than in the control group. There was no significant difference in sunscreen use between the groups. Using dermatologic medical history, Fitzpatrick skin type and sunscreen use as covariates, we showed that hair dye use carried a higher PCD risk (odds ratio [OR] before adjustment: 2.06, confidence interval [CI]: 1.60-2.65; OR after adjustment: 2.74, CI: 1.88-4.00). Moreover, henna users had a higher risk of PCD (OR before adjustment: 5.51, CI: 4.07-7.47; OR after adjustment: 7.02, CI: 4.59-10.74), indicating a significant increase in the risk of PCD with henna dye use. Contact dermatitis history was more prevalent in henna users than in those using other hair dyes in the PCD group (17.23% vs. 11.55%). ConclusionHair dye use is a risk factor for PCD. The risk significantly increased when henna hair dye was used by those with a history of contact dermatitis. Fri, 01 Dec 2023 00:00:00 GMT https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/63882 2023-12-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64281 Title: Increased dental comorbidities in patients with psoriasis: a nationwide population-based cohort study in Korea Authors: Kwak, Eun-Jung; Choi, Yun Jin; Kim, Han-Na; Kim, Ko Eun; Jeon, Jiehyun; Baek, Yoo Sang Abstract: Background Limited data are available regarding the association between psoriasis and common dental conditions.Objectives To investigate the risk of potential dental comorbidities in patients with psoriasis.Methods We conducted a nationwide population-based cohort study to analyse the claims data of patients with psoriasis (n = 15 165) and age- and sex-matched controls (n = 75 825). The incidence risk of the following potential dental conditions was analysed: dental caries, pulp and periapical disease, periodontal disease, gingival changes and tooth loss.Results After adjusting for potential cofactors, the adjusted hazard ratios (aHRs) of dental caries [1.105; 95% confidence interval (CI) 1.078-1.132], pulp and periapical disease (1.07; 95% CI 1.044-1.096) and periodontal disease (1.108; 95% CI 1.088-1.129) were significantly higher than those in the control cohort (P < 0.001). However, among the subset of patients with psoriasis who received systemic antipsoriatic treatment (n = 4275), the aHR risk of all potential dental comorbidities was not significantly higher from that of the control cohort.Conclusions Patients with psoriasis have an increased risk of dental comorbidities, and systemic antipsoriatic treatment may help mitigate this increased risk. Wed, 01 Nov 2023 00:00:00 GMT https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64281 2023-11-01T00:00:00Z https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64347 Title: Periorbital Skin Rejuvenation of Asian Skin Using Microneedle Fractional Radiofrequency Authors: Kim, Ko Eun; Park, Jong Heon; Seul, Tae Woong; Kim, Il-Hwan; Ryu, Hwa Jung Abstract: Background: The periorbital area plays an important role cosmetically. Periorbital wrinkles are attributed to long-term, repeated use of orbicularis oris muscles and UV-induced dermal collagen degeneration. Fractional microneedle radiofrequency (RF) treats scars and laxity by creating vertical channels of injury in the dermis, triggering a scarless healing cascade and neocollagenesis. Objective: To evaluate the effect and safety of a novel fractional microneedle RF device on periorbital wrinkles based on several objective indicators.Methods: Eleven healthy Korean patients aged 30 to 75 years with periorbital wrinkles were included in this study. Wrinkle grades were evaluated using the Fitzpatrick wrinkle assessment scale (WAS). The melanin and erythema index, transepidermal water loss (TEWL), and three parameters for elasticity were recorded. Skin biopsies were obtained in patients who consented.Results: All patients exhibited wrinkle improvement in the lateral periorbital area, and two patients also showed efficacy in the lower eyelid area. There was a statistically significant decrease in WAS and a significant improvement in the melanin index of V4 and V5. TEWL also showed a considerable decline on V4 and V5, suggesting that the water content of the skin increased with repeated laser sessions. A peak increase in viscoelasticity and a decrease in retraction time following the first laser application were observed. In the histopathologic examination, the dermis had a denser collagen and elastin content.Conclusion: Microneedle fractional RF resulted in statistically significant long-term clinical improvement of periorbital wrinkles and enhanced pigmentation and skin hydration. Sun, 01 Oct 2023 00:00:00 GMT https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64347 2023-10-01T00:00:00Z