Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice
- Authors
- Kim, Tae-Soo; Han, Dong-Hee; Lee, Yeon-Ju; Son, Gi Hoon; Kim, Kyungjin; Kim, Chang-Ju; Cho, Sehyung
- Issue Date
- 1-Dec-2013
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- adrenal clock; exercise; biological rhythm; body temperature; home cage activity; middle-aged female mouse
- Citation
- ANIMAL CELLS AND SYSTEMS, v.17, no.6, pp 397 - 405
- Pages
- 9
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANIMAL CELLS AND SYSTEMS
- Volume
- 17
- Number
- 6
- Start Page
- 397
- End Page
- 405
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10055
- DOI
- 10.1080/19768354.2013.860916
- ISSN
- 1976-8354
2151-2485
- Abstract
- We recently established an adrenal clock-disrupted transgenic mouse line (BMAS) that exhibits a dampened rhythm of corticosterone secretion and reduced amplitude of day/night activity. Here, we observe that voluntary wheel running increases the robustness and amplitude of both body temperature and home cage activity (HCA) rhythms in wild-type, but not in BMAS mice, but without affecting estrous cycle. Surprisingly, wheel running alters the HCA waveform of BMAS females in a way that preferentially increases the late nighttime (ZT21-ZT24) HCA. These results indicate that adrenal clock disruption causes the animals to respond differently to the voluntary exercise cue in middle-aged female mice.
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- Appears in
Collections - 1. Basic Science > Department of Legal Medicine > 1. Journal Articles
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