Detailed Information

Cited 10 time in webofscience Cited 12 time in scopus
Metadata Downloads

CD11c(+) Cells Partially Mediate the Renoprotective Effect Induced by Bone Marrow-Derived Mesenchymal Stem Cells

Authors
Kim, Myung-GyuKim, Su HeeNoh, HyunjinKo, Yoon SookLee, Hee YoungJo, Sang-KyungCho, Won YongKim, Hyoung Kyu
Issue Date
6-Aug-2013
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.8, no.8
Indexed
SCIE
SCOPUS
Journal Title
PLOS ONE
Volume
8
Number
8
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10464
DOI
10.1371/journal.pone.0072544
ISSN
1932-6203
Abstract
Previous studies have shown that induction of immune tolerance by mesenchymal stem cells (MSCs) is partially mediated via monocytes or dendritic cells (DCs). The purpose of this study was to determine the role of CD11c(+) cells in MSC-induced effects on ischemia/reperfusion injury (IRI). IRI was induced in wildtype (WT) mice and CD11c(+)-depleted mice following pretreatment with or without MSCs. In the in-vitro experiments, the MSC-treated CD11c(+) cells acquired regulatory phenotype with increased intracellular IL-10 production. Although splenocytes cocultured with MSCs showed reduced T cell proliferation and expansion of CD4(+)FoxP3(+) regulatory T cells (Tregs), depletion of CD11c(+) cells was associated with partial loss of MSCs effect on T cells. In in-vivo experiment, MSCs' renoprotective effect was also associated with induction of more immature CD11c(+) cells and increased FoxP3 expression in I/R kidneys. However all these effects induced by the MSCs were partially abrogated when CD11c(+) cells were depleted in the CD11c(+)-DTR transgenic mice. In addition, the observation that adoptive transfer of WT CD11c(+) cells partially restored the beneficial effect of the MSCs, while transferring IL-10 deficient CD11c(+) cells did not, strongly suggest the important contribution of IL-10 producing CD11c(+) cells in attenuating kidney injury by MSCs. Our results suggest that the CD11c(+) cell-Tregs play critical role in mediating renoprotective effect of MSCs.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jo, Sang Kyung photo

Jo, Sang Kyung
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE