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Development and validation of novel scoring system for the prediction of disease recurrence following resection of colorectal liver metastasis

Authors
Kim, Wan-JoonLim, Tae-WanKang, Sang-HeePark, Pyoung JaeChoi, Sae ByeolLee, Sun-ilMin, Byung-WookKim, Wan-Bae
Issue Date
Feb-2020
Publisher
ELSEVIER SINGAPORE PTE LTD
Keywords
CA19-9; CRLM; Disease free survival; NLR; Scoring system
Citation
Asian Journal of Surgery, v.43, no.2, pp.438 - 446
Indexed
SCIE
SCOPUS
Journal Title
Asian Journal of Surgery
Volume
43
Number
2
Start Page
438
End Page
446
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1049
DOI
10.1016/j.asjsur.2019.06.001
ISSN
1015-9584
Abstract
Background: The aim of this study was to identify predictive factors for the recurrence of colorectal cancer liver metastasis (CRLM) and then to develop a corresponding novel scoring system that should improve the sensitivity of predicting recurrence in patients with CRLM. Methods: A total of 295 consecutive CRLM patients were enrolled in our institution between January 2002 and December 2015. Multivariate analyses were performed to identify the variables associated with disease recurrence and established the novel scoring system based on it. Results: The scoring system considered seven variables: synchronosity, CA19-9 level, number of liver metastasis, largest size of liver metastasis, resection margin of hepatic lesion, neutrophil-to-lymphocyte ratio and prognostic nutritional index. The area under the curve of ROC was 0.824 (95% confidence interval 0.767-0.882); the sensitivity of our scoring system was 87.9%, specificity was 66.7%, positive predictive value was 20.6%, and negative predictive value was 20.9%. Conclusion: For patients with CRLM undergoing curative hepatic resection, our novel scoring system would improve the sensitivity for prediction of disease recurrence in Case of CRLM patients. (C) 2019 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V.
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2. Clinical Science > Department of Transplantation and Vascular Surgery > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles

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Min, Byung Wook
Guro Hospital (Department of Colon and Rectal Surgery, Guro Hospital)
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