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Cited 6 time in webofscience Cited 5 time in scopus
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Helicobacter pylori eradication on iatrogenic ulcer by endoscopic resection of gastric tumour: A prospective, randomized, placebo-controlled multi-centre trial

Authors
Kim, Sang GyunSong, Ho JuneChoi, Il JuCho, Won YoungLee, Jeong HoonKeum, BoraLee, Yong ChanKim, Jae GyuPark, Sue K.Park, Byung-JooJung, Hyun Chae
Issue Date
May-2013
Publisher
ELSEVIER SCIENCE INC
Keywords
Endoscopic resection; Eradication; Healing; Helicobacter pylori; Iatrogenic ulcer
Citation
DIGESTIVE AND LIVER DISEASE, v.45, no.5, pp 385 - 389
Pages
5
Indexed
SCI
SCIE
SCOPUS
Journal Title
DIGESTIVE AND LIVER DISEASE
Volume
45
Number
5
Start Page
385
End Page
389
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10778
DOI
10.1016/j.dld.2012.12.009
ISSN
1590-8658
1878-3562
Abstract
Introduction: The role of Helicobacter pylori (H. pylori) eradication has not been clarified in the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. The aim of this study was to evaluate whether H. pylori eradication could facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. Methods: A total of 232 patients with H. pylori-positive early gastric cancer or gastric adenoma underwent endoscopic resection and were randomly allocated to eradication or placebo group in a prospective, double-blinded, and placebo-controlled manner. The primary outcome was measured by healing rate of ulcer, and the secondary outcomes by reduction rate of ulcer size, relief rate from ulcer-related symptoms, and adverse event rates. Results: The healing rate of ulcer was 53% in eradication group and 51.6% in placebo group, respectively (p value = 0.95). The reduction rate of ulcer size, relief rate from ulcer-related symptoms and adverse event rates were also not different between two groups. In multivariate analysis, initial ulcer size more than 3 cm and histology of cancer were significant factors affecting iatrogenic ulcer healing. Conclusions: H. pylori eradication did not facilitate iatrogenic ulcer healing at early and late phase after endoscopic resection of gastric neoplasm. (C) 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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Keum, Bora
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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