Clinical Significance of Galectin-7 in Epithelial Ovarian Cancer
- Authors
- Kim, Ha-Jeong; Jeon, Hye-Kyung; Lee, Jae-Kwan; Sung, Chang Ohk; Do, In-Gu; Choi, Chel Hun; Kim, Tae-Joong; Kim, Byoung-Gie; Bae, Duk-Soo; Lee, Jeong-Won
- Issue Date
- Apr-2013
- Publisher
- INT INST ANTICANCER RESEARCH
- Keywords
- Galectin-7; ovarian cancer; siRNA; prognosis
- Citation
- ANTICANCER RESEARCH, v.33, no.4, pp 1555 - 1561
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- ANTICANCER RESEARCH
- Volume
- 33
- Number
- 4
- Start Page
- 1555
- End Page
- 1561
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10881
- ISSN
- 0250-7005
1791-7530
- Abstract
- Background: Galectin-7 (GAL-7) has been highlighted as an important marker in many types of cancers by either inhibiting or promoting tumor growth. In this novel study, we assessed the association of GAL-7 with clinicopathological variables and survival outcomes in epithelial ovarian cancer (EOC) and investigated the role of GAL-7 in proliferation of ovarian cancer cell lines. Materials and Methods: The expression of GAL-7 was determined in 63 formalin-fixed, paraffin-embedded EOC tissues using an immunohistochemical method and we compared various associated clinicopathological factors. To evaluate the role of GAL-7 in cell proliferation, we performed proliferation assays with GAL-7 siRNA using ovarian cancer cell lines, including A2780-PAR cells. Results: Immunohistochemical analysis revealed that GAL-7 expression was primarily detected in nuclei and occasionally in the nucleus and cytoplasm. High GAL-7 expression was associated with greater age (p=0.016), high mortality (p=0.025), and poor overall survival outcome (p=0.029). In addition, the residual tumor volume was larger in the high-expression group compared to the low-expression group, although the difference was not statistically significant (p=0.059). Down-regulation of GAL-7 using siRNA resulted in the inhibition of cell proliferation of A2780-PAR cells. Conclusion: We observed that high GAL-7 might be associated with poor survival outcome in patients with EOC, and may be fitnctionally involved in cell proliferation.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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