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Cited 31 time in webofscience Cited 34 time in scopus
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A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder

Authors
Lee, Heon-JeongWoo, Hyun GooGreenwood, Tiffany A.Kripke, Daniel F.Kelsoe, John R.
Issue Date
20-Feb-2013
Publisher
ELSEVIER SCIENCE BV
Keywords
Seasonal pattern; Bipolar disorder; Genome-wide association
Citation
JOURNAL OF AFFECTIVE DISORDERS, v.145, no.2, pp.200 - 207
Indexed
SCIE
SSCI
SCOPUS
Journal Title
JOURNAL OF AFFECTIVE DISORDERS
Volume
145
Number
2
Start Page
200
End Page
207
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10968
DOI
10.1016/j.jad.2012.07.032
ISSN
0165-0327
Abstract
Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08 x 10(-7), OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12 x 10(-7), OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder. (C) 2013 Published by Elsevier B.V.
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Lee, Heon Jeong
Anam Hospital (Department of Psychiatry, Anam Hospital)
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