A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder
- Lee, Heon-Jeong; Woo, Hyun Goo; Greenwood, Tiffany A.; Kripke, Daniel F.; Kelsoe, John R.
- Issue Date
- ELSEVIER SCIENCE BV
- Seasonal pattern; Bipolar disorder; Genome-wide association
- JOURNAL OF AFFECTIVE DISORDERS, v.145, no.2, pp.200 - 207
- Journal Title
- JOURNAL OF AFFECTIVE DISORDERS
- Start Page
- End Page
- Objective: The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. Method: We have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes. Results: A bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08 x 10(-7), OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549 bp showed a more significant association (P=2.12 x 10(-7), OR=0.4). Conclusions: These data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder. (C) 2013 Published by Elsevier B.V.
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- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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