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Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade

Authors
Yim, Hyung JoonHwang, Seong Gyu
Issue Date
Sep-2013
Publisher
대한간학회
Keywords
Antiviral resistance; Chronic hepatitis B; Hepatitis B virus; Nucleoside analogue; Nucleotide analogue; Treatment
Citation
Clinical and Molecular Hepatology, v.19, no.3, pp.195 - 209
Indexed
SCOPUS
KCI
Journal Title
Clinical and Molecular Hepatology
Volume
19
Number
3
Start Page
195
End Page
209
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11320
DOI
10.3350/cmh.2013.19.3.195
ISSN
2287-2728
Abstract
Although much advancement has been achieved in the treatment of chronic hepatitis B, antiviral resistance is still a challenging issue. Previous generation antiviral agents have already developed resistance in a number of patients, and it is still being used especially in resource limited countries. Once antiviral resistance occurs, it predisposes to subsequent resistance, resulting in multidrug resistance. Therefore, prevention of initial antiviral resistance is the most important strategy, and appropriate choice and modification of therapy would be the cornerstone in avoiding treatment failures. Until now, management of antiviral resistance has been evolving from sequential therapy to combination therapy. In the era of tenofovir, the paradigm shifts again, and we have to decide when to switch and when to combine on the basis of newly emerging clinical data. We expect future eradication of chronic hepatitis B virus infection by proper prevention and optimal management of antiviral resistance.
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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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