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Cited 20 time in webofscience Cited 19 time in scopus
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Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder

Authors
Crisafulli, ConcettaShim, Dong SukAndrisano, CostanzaPae, Chi-UnChiesa, AlbertoHan, ChangsuPatkar, Ashwin A.Lee, Soo-JungSerretti, AlessandroDe Ronchi, Diana
Issue Date
30-Jun-2012
Publisher
ELSEVIER IRELAND LTD
Keywords
CREB1; CREBBP; CREM; Major depressive disorder; Bipolar disorder
Citation
PSYCHIATRY RESEARCH, v.198, no.1, pp.39 - 46
Indexed
SCIE
SSCI
SCOPUS
Journal Title
PSYCHIATRY RESEARCH
Volume
198
Number
1
Start Page
39
End Page
46
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11976
DOI
10.1016/j.psychres.2011.08.022
ISSN
0165-1781
Abstract
Some evidence suggests an association between genetic variants within the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), CREB binding protein (CREBBP) and cAMP response element-modulator (CREM) and several psychiatric disorders. The present study investigated whether some single nucleotide polymorphisms (SNPs) within these genes could be associated with major depressive disorder (MDD) and bipolar disorder (BD) and whether they could predict clinical outcomes in Korean inpatients treated with antidepressants and mood stabilizers, respectively. The sample comprised 145 patients with MDD, 132 patients with BD and 170 psychiatrically healthy controls. Participants were genotyped for 14 SNPs within CREB1, CREBBP and CREM. Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale and Young Mania Rating Scale for patients with MDD and BD, respectively, were recorded. All p-values were 2-tailed, and statistical significance was conservatively set at the 0.006 level in order to reduce the likelihood of false positive results. We failed to observe any association of the 14 SNPs genotypes or alleles with clinical improvement, response and remission rates as well as final outcomes in any of such disorders. Our findings suggest that the 14 SNP under investigation in our study do not influence diagnosis and treatment response in patients with MDD and BD. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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구로병원 (Department of Psychiatry, Ansan Hospital)
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