Is chemotherapy in elderly patients with metastatic or recurrent gastric cancer as tolerable and effective as in younger patients?
- Authors
- Kim, Seung Tae; Park, Kyong Hwa; Oh, Sang Cheul; Seo, Jae Hong; Shin, Sang Won; Kim, Jun Suk; Kim, Yeul Hong
- Issue Date
- Jun-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- elderly patients; gastric cancer; chemotherapy
- Citation
- ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, v.8, no.2, pp 194 - 200
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
- Volume
- 8
- Number
- 2
- Start Page
- 194
- End Page
- 200
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12072
- DOI
- 10.1111/j.1743-7563.2011.01501.x
- ISSN
- 1743-7555
1743-7563
- Abstract
- Aim: To analyze the chemotherapy regimens and outcomes of advanced gastric cancer (AGC) patients older than 70 years of age. Methods: Between May 2001 and October 2009, 1135 patients with metastatic or recurrent gastric cancer received palliative chemotherapy. Of these patients 56 (4.9%) were =70 years old and were analyzed retrospectively. Results: The median age at the time of first-line chemotherapy was 73 years (range, 7085) and the median Charlson comorbidity index was 0 (05). In all 17 patients (30%) received surgery with curative or palliative intent; 43 (77%) were treated by doublet or triplet first-line chemotherapy regimens and 13 patients (23%) received single agent chemotherapy. Median progression-free survival for first-line chemotherapy was 3.97 months (95% CI 2.055.89) with an overall response rate of 26%. After the first-line chemotherapy, only 18 of 56 (32%) patients received second-line chemotherapy. The median overall survival (OS) was 12.4 months (95% CI 2.8121.99). In multivariate analysis, receiving surgery and disease control for first-line chemotherapy were independent prognostic factors for increased OS for all 56 patients. Conclusion: Patients older =70 years with metastatic or recurrent gastric cancer might achieve clinical benefit from chemotherapy. Receiving surgery and response of over more stable disease for first-line chemotherapy were independent prognostic factors for increased OS.
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Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
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