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Cited 25 time in webofscience Cited 32 time in scopus
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Effectiveness of three times daily lansoprazole/amoxicillin dual therapy for Helicobacter pylori infection in Korea

Authors
Kim, Seung YoungJung, Sung WooKim, Jeong HanKoo, Ja SeolYim, Hyung JoonPark, Jong JaeChun, Hoon JaiLee, Sang WooChoi, Jai Hyun
Issue Date
Jan-2012
Publisher
WILEY-BLACKWELL
Keywords
amoxicillin; administration and dosage; combination; drug therapy; Helicobacter pylori; drug therapy; proton pump inhibitors; administration and dosage
Citation
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, v.73, no.1, pp 140 - 143
Pages
4
Indexed
SCI
SCIE
SCOPUS
Journal Title
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
Volume
73
Number
1
Start Page
140
End Page
143
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12535
DOI
10.1111/j.1365-2125.2011.04048.x
ISSN
0306-5251
1365-2125
Abstract
AIM We compared three times daily dual therapy with standard triple therapy for effectiveness and safety in H. pylori infection. METHODS Two hundred and four H. pylori positive patients with peptic ulcer were randomly assigned to one of two regimens: (i) triple therapy with amoxicillin, clarithromycin and lansoprazole twice daily for 2 weeks or (ii) dual therapy with amoxicillin and lansoprazole three times daily for 2 weeks. The success of eradication was evaluated 4 to 5 weeks after completing treatment. RESULTS The eradication rate was 82.8% in the triple therapy group and 78.4% in the dual therapy group by per protocol analysis. This difference was not significant (P = 0.573). Adverse events were more frequent in the triple therapy group than in the dual therapy group (P = 0.002). CONCLUSIONS Because dual therapy had fewer side effects than triple therapy and a similar eradication rate, dual therapy may provide an acceptable alternative first line therapy for H. pylori eradication in Korea.
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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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