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Increased serum activity of matrix metalloproteinase-9 in patients with acute variceal bleedingopen access

Authors
Kwon O.S.Jung H.S.Bae K.S.Jung Y.K.Kim Y.S.Choi D.J.Kim Y.S.Kim J.H.
Issue Date
2012
Keywords
Esophageal and gastric varices; Hemorrhage; Matrix metalloproteinase 2; Matrix metalloproteinase 9
Citation
Gut and Liver, v.6, no.2, pp.249 - 255
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
Gut and Liver
Volume
6
Number
2
Start Page
249
End Page
255
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12764
DOI
10.5009/gnl.2012.6.2.249
ISSN
1976-2283
Abstract
Background/Aims: Matrix metalloproteinases (MMP)-2 and -9 can degrade essential components of vascular integrity. The aim of this study was to investigate the association between those MMPs and variceal bleeding (VB). Methods: Fifteen controls, 12 patients with acute ulcer bleeding (UB) group, 37 patients with varix (V group), and 35 patients with acute VB group were enrolled. Serum was obtained to measure MMP-2 and -9 activity by zymogram protease assays. Results: The activity levels of these compounds were compared with the controls' median value. The median MMP- 9 activity was 1.0 in controls, 1.05 in the UB group, 0.43 in the V group, and 0.96 in the VB group. The level of MMP- 9 activity was higher in the VB group than in the V group (p<0.001). In the VB group, there was a signifi cant decrease in MMP-9 activity over time after bleeding (p<0.001). The median MMP-2 activity level was 1.0 in controls, 1.01 in the UB group, 1.50 in the V group, and 1.55 in the VB group. The level of MMP-2 activity was similar in the VB and V groups. Conclusions: The level of MMP-9 activity increased in association with VB. The role of MMP-9 in the pathogenesis of VB should be verifi ed.
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Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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