Association between serum ceruloplasmin levels and arterial stiffness in korean men with type 2 diabetes mellitus
- Authors
- Lee M.J.; Jung C.H.; Hwang J.Y.; Shin M.S.; Yu J.H.; Lee W.J.; Park J.-Y.
- Issue Date
- 2012
- Citation
- Diabetes Technology and Therapeutics, v.14, no.12, pp 1091 - 1097
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Diabetes Technology and Therapeutics
- Volume
- 14
- Number
- 12
- Start Page
- 1091
- End Page
- 1097
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12772
- DOI
- 10.1089/dia.2012.0177
- ISSN
- 1520-9156
1557-8593
- Abstract
- Background: Increased oxidative stress contributes to the development of arterial stiffness. Arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), has been known to be correlated with oxidative stress. Serum ceruloplasmin (CP), a copper-carrying protein, may indicate the overall level of oxidative stress in the body. The present study investigated whether serum CP levels are associated with baPWV in Korean men with type 2 diabetes mellitus (DM). Subjects and Methods: Serum CP levels and conventional risk factors were measured in 760 Korean men with type 2 DM. Arterial stiffness was assessed by baPWV obtained with an automatic device (model VP-1000; Colin, Komaki, Japan). Results: Correlation analysis indicated a significant positive association between serum CP and baPWV (r=0.109, P=0.003). Age-adjusted baPWV increased gradually according to serum CP quartiles (Q1, 1,500.3±18.4 cm/s; Q2, 1,511.6±17.8 cm/s; Q3, 1,551.8±17.9 cm/s; Q4, 1,622.1±17.8 cm/s; P for trend<0.001). Multivariate linear regression analysis showed that serum CP was independently associated with baPWV in various models. Conclusions: A positive relationship was identified between CP and baPWV in adult male subjects with type 2 DM, which was independent of conventional cardiovascular risk factors. Further studies are needed to confirm whether CP contributes to the pathogenesis of increased arterial stiffness in subjects with type 2 DM. © Mary Ann Liebert, Inc.
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Collections - 2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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