Significant reduction of atrial defibrillation threshold and inducibility by catheter ablation of atrial fibrillation
- Authors
- Hwang E.-S.; Nam G.B.; Joung B.; Park J.; Lee J.S.; Shim J.; Uhm J.-S.; Lee M.H.; Pak H.-N.
- Issue Date
- 2012
- Keywords
- atrial fibrillation; catheter ablation; defibrillation threshold; inducibility
- Citation
- PACE - Pacing and Clinical Electrophysiology, v.35, no.12, pp 1428 - 1435
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- PACE - Pacing and Clinical Electrophysiology
- Volume
- 35
- Number
- 12
- Start Page
- 1428
- End Page
- 1435
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12796
- DOI
- 10.1111/j.1540-8159.2012.03517.x
- ISSN
- 0147-8389
1540-8159
- Abstract
- Background: Radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) has antiarrhythmic effects by multiple mechanisms. We hypothesized that RFCA curtails atrial defibrillation threshold (A-DFT) and postablation induction pacing cycle length (iPCL), making critical mass reduction one potential mechanism by which antiarrhythmic effect is achieved. Methods: We included 289 patients with AF (male 77.9%, 55.7 ± 10.8 years old; 197 paroxysmal AF: 92 persistent AF) who underwent RFCA. A-DFT (serial internal cardioversion 2, 3, 5, 7, and 10 J) and iPCL (serial 10 mA 10-second atrial pacing with pacing cycle length 250, 200, 190, 180, 170, 160, and 150 ms) were evaluated before and after RFCA. Results: (1) RFCA of AF reduced the A-DFT from 6.7 ± 3.7 J to 3.0 ± 3.0 J (P < 0.001). (2) AF ablation reduced AF inducibility from 95.4% before the procedure to 56.3% after the procedure (P < 0.001), and the iPCL from 194.8 ± 32.6 to 160.9 ± 26.2 ms (P < 0.001). (3) In patients who underwent a greater number of ablation lines, the post-RFCA A-DFT (P < 0.001) was lower, and %ΔA-DFT (P = 0.003) and proportion of atrial tachycardia (P = 0.022) were higher than those with a lower number of ablation lines. Conclusion: AF ablation significantly reduced A-DFT, AF inducibility, and iPCL, and the degree of their reduction was related to the number of ablation lines. (PACE 2012;35:1428-1435) ©2012, The Authors. Journal compilation ©2012 Wiley Periodicals, Inc.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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