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Plasma Brain-derived Neurotrophic Factor in Hemodialysis Patientsopen access

Authors
Shin, Seok JoonYoon, Hye EunChung, SungjinKim, Yong GuKim, Dai-Jin
Issue Date
2012
Publisher
IVYSPRING INT PUBL
Keywords
Brain-derived neurotrophic factor; Cytokine; Hemodialysis; Uremia; Inflammation
Citation
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, v.9, no.9, pp 772 - 777
Pages
6
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume
9
Number
9
Start Page
772
End Page
777
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12851
DOI
10.7150/ijms.5063
ISSN
1449-1907
Abstract
Objective: Brain-derived neurotrophic factor (BDNF) is a neurotrophin which modulates neuronal survival and proliferation. Recently, plasma BDNF is associated with inflammatory conditions. The present study was to investigate the changes of the plasma BDNF level in hemodialysis patients and to evaluate the relationship between the plasma BDNF and uremic inflammation. Method: We measured the plasma BDNF, serum IL-2, IL-4, IFN-gamma and TNF-alpha in hemodialysis patients and control subjects. In addition, we investigated the associations of the plasma BDNF with clinical or biochemical parameters. Results: The plasma BDNF level was significantly higher in hemodialysis patients than in the control subjects (median, 312.3 vs. 630.3 pg/ml, p < 0.05). In subgroup analysis, hemodialysis patients with diabetes showed higher values of the plasma BDNF than the patients without diabetes. However, there were no significant differences in age and gender subgroups of the hemodialysis patients. The logBDNF was positively correlated with hs-CRP and IFN-gamma, and negatively correlated with serum albumin. In multivariate regression analysis, the logBDNF was independently associated with the presence of diabetes (beta-coefficient = 0.399, p = 0.041) and IFN-gamma (beta-coefficient = 0.538, p = 0.003). Conclusion: The plasma BDNF may increase in hemodialysis patients, and more prominently in the patients with diabetes. Furthermore, the plasma BDNF might reflect inflammatory condition in hemodialysis patients.
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