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Cited 12 time in webofscience Cited 11 time in scopus
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Adipose-Derived Stem Cells Improve Renal Function in a Mouse Model of IgA Nephropathy

Authors
Hyun, Young YoulKim, In OkKim, Mi HyungNam, Deok HwaLee, Mi HwaKim, Jung EunSong, Hye KyoungCha, Jin JooKang, Young SunLee, Ji EunKim, Hyun WookHan, Jee YoungCha, Dae Ryong
Issue Date
2012
Publisher
SAGE PUBLICATIONS INC
Keywords
Adipose-derived stem cells (ASCs); HIGA mice; Th1 cytokine; Glomerulosclerosis; Proteinuria
Citation
CELL TRANSPLANTATION, v.21, no.11, pp 2425 - 2439
Pages
15
Indexed
SCI
SCIE
SCOPUS
Journal Title
CELL TRANSPLANTATION
Volume
21
Number
11
Start Page
2425
End Page
2439
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12872
DOI
10.3727/096368912X639008
ISSN
0963-6897
1555-3892
Abstract
T-cell dysregulation plays an important role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Adipose-derived stem cells (ASCs) have been reported to be able to prevent tissue damage through immune-modulating effects. To evaluate the effects of ASCs in high IgA ddY (HIGA) mice, ASCs were isolated from HIGA mice with different stages of IgAN before and after disease onset. ASCs were injected at a dose of 5 x 10(6) cells/kg body weight through the tail vein every 2 weeks for 3 months. Although the administered ASCs were rarely detected in the glomeruli, 24-h proteinuria was markedly decreased in all ASC-treated groups. Although glomerular deposition of IgA was not significantly different among groups, mesangial proliferation and glomerulosclerosis were dramatically decreased in most ASC treatment groups. In addition, levels of fibrotic and inflammatory molecules were markedly decreased by ASC treatment. Interestingly, ASC therapy significantly decreased Th1 cytokine activity in the kidney and caused a shift to Th2 responses in spleen T-cells as determined by FACS analysis. Furthermore, conditioned media from ASCs abrogated aggregated IgA-induced Th1 cytokine production in cultured HIGA mesangial cells. These results suggest that the beneficial effects of ASC treatment in IgAN occur via paracrine mechanisms that modulate the Th1/Th2 cytokine balance. ASCs are therefore a promising new therapeutic agent for the treatment of IgAN.
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Cha, Dae Ryong
Ansan Hospital (Department of Nephrology and Hypertension, Ansan Hospital)
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