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Cited 18 time in webofscience Cited 20 time in scopus
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The effect of the respiratory cycle on liver stiffness values as measured by transient elastography

Authors
Yun, M. H.Seo, Y. S.Kang, H. S.Lee, K. G.Kim, J. H.An, H.Yim, H. J.Keum, B.Jeen, Y. T.Lee, H. S.Chun, H. J.Um, S. H.Kim, C. D.Ryu, H. S.
Issue Date
Sep-2011
Publisher
WILEY
Keywords
expiration; FibroScan; inspiration; overestimation
Citation
JOURNAL OF VIRAL HEPATITIS, v.18, no.9, pp.631 - 636
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF VIRAL HEPATITIS
Volume
18
Number
9
Start Page
631
End Page
636
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13174
DOI
10.1111/j.1365-2893.2010.01376.x
ISSN
1352-0504
Abstract
The findings of several studies suggest that liver stiffness values can be affected by the degree of intrahepatic congestion respiration influence intrahepatic blood volume and may affect liver stiffness. We evaluated the influence of respiration on liver stiffness. Transient elastography (TE) was performed at the end of inspiration and at the end of expiration in patients with chronic liver disease. The median values obtained during the inspiration set and during the expiration set were defined as inspiratory and expiratory liver stiffness, respectively. A total of 123 patients with chronic liver disease were enrolled (mean age 49 years; 64.2% men). Liver cirrhosis coexisted in 29 patients (23.6%). Expiratory liver stiffness was significantly higher than inspiratory liver stiffness (8.7 vs 7.9 kPa, P = 0.001), while the expiratory interquartile range/median ratio (IQR ratio) did not differ from the inspiratory IQR ratio. Expiratory liver stiffness was significantly higher than inspiratory liver stiffness in 49 (39.8%) patients (HE group), expiratory liver stiffness was significantly lower than inspiratory stiffness in 15 (12.2%) patients, and there was no difference in 59 (48.0%) patients. Liver cirrhosis was more frequent in those who had a lower liver stiffness reading in expiration, and only the absence of liver cirrhosis was significantly associated with a higher reading in expiration in multivariate analysis. In conclusion, liver stiffness was significantly elevated during expiration especially in patients without liver cirrhosis. The effect of respiration should be kept in mind during TE readings.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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