Clinicopathologic characteristics of granulosa cell tumors of the ovary: a multicenter retrospective studyopen access
- Authors
- Lee, In Ho; Choi, Chel Hun; Hong, Dae Gy; Song, Jae Yun; Kim, Young Jae; Kim, Kyung Tai; Lee, Kyu Wan; Park, Il Soo; Bae, Duk Soo; Kim, Tae Jin
- Issue Date
- Sep-2011
- Publisher
- KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
- Keywords
- Clinical study; Granulosa cell tumor; Ovary; Pregnancy; Recurrence
- Citation
- JOURNAL OF GYNECOLOGIC ONCOLOGY, v.22, no.3, pp 188 - 195
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCICANDI
- Journal Title
- JOURNAL OF GYNECOLOGIC ONCOLOGY
- Volume
- 22
- Number
- 3
- Start Page
- 188
- End Page
- 195
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13183
- DOI
- 10.3802/jgo.2011.22.3.188
- ISSN
- 2005-0380
2005-0399
- Abstract
- Objective: To evaluate the clinicopathologic characteristics and prognostic factors of ovarian granulosa cell tumors. Methods: Medical records of 113 patients presenting between January 1995 and December 2007 were retrospectively reviewed. Results: One-hundred two patients had adult type disease, with a mean age of 46.2 years (range, 18 to 83 years) and a mean follow-up period of 54.7 months (range, 1 to 155 months). The distribution of FIGO stages was 86 patients at stage I, 11 at stage II, and 5 at stage III. During follow-up, ten patients recurred at a mean time of 48 months (range, 4 to 109 months). Among them, three patients died after a mean of 57 months (range, 25 to 103 months). In recurrence analysis, advanced stage (p=0.032) and presence of residual disease (p=0.012) were statistically significant, and age<40 years, premenopause and positive washing cytology were marginally significant (p<0.1). In multivariate analysis, stage was the only factor associated with recurrence; adjuvant chemotherapy and fertility-sparing surgery were not statistically significant. Among 36 patients with fertility-sparing operations, eight patients had nine pregnancies and delivered seven babies. Eleven patients had juvenile type tumors; the mean age was 20.0 years (range, 8 to 45 years) and the mean follow-up period was 69.8 months (range, 20 to 156 months). The distribution of FIGO stage was nine patients at stage I and two at stage III. There were no recurrences or deaths reported. Four patients had seven pregnancies and delivered six babies. Conclusion: Stage is the only factor associated with disease-free survival, and fertility-sparing surgery may be a treatment option for women with early-stage disease who want to retain fertility.
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Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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