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Cited 34 time in webofscience Cited 41 time in scopus
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Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia

Authors
Serretti, AlessandroChiesa, AlbertoPorcelli, StefanoHan, ChangsuPatkar, Ashwin A.Lee, Soo-JungPark, Moon HoPae, Chi-Un
Issue Date
30-Aug-2011
Publisher
ELSEVIER IRELAND LTD
Keywords
Tryptophan hydroxylase 2; Major depression; Bipolar disorder; Schizophrenia
Citation
PSYCHIATRY RESEARCH, v.189, no.1, pp.26 - 32
Indexed
SCIE
SSCI
SCOPUS
Journal Title
PSYCHIATRY RESEARCH
Volume
189
Number
1
Start Page
26
End Page
32
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13237
DOI
10.1016/j.psychres.2011.02.001
ISSN
0165-1781
Abstract
The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antidepressants, mood stabilizers and antipsychotics, respectively. One hundred forty-five patients with MD, 132 patients with BD, 221 patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for six TPH2 SNPs (rs4570625, rs10748185, rs11179027, rs1386498, rs4469933, and rs17110747). Baseline and final clinical measures, including the Montgomery-Asberg Depression Rating Scale (MADRS), Young Mania Rating Scale and Positive and Negative Syndrome Scale, for patients with MD, BD and schizophrenia, respectively were recorded. None of the SNPs under investigation were associated with MD, BD and schizophrenia. However, in patients with MD, the rs4570625-rs10748185 G-A haplotype was significantly associated with higher endpoint MADRS severity, though not with response. Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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Ansan Hospital (Department of Neurology, Ansan Hospital)
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