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Cited 47 time in webofscience Cited 35 time in scopus
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Gastroesophageal Reflux Disease in Type II Diabetes Mellitus With or Without Peripheral Neuropathy

Authors
Lee, Sehe DongKeum, BoraChun, Hoon JaiBak, Young-Tae
Issue Date
Jul-2011
Publisher
KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
Keywords
Diabetes mellitus; Type 2; Erosive esophagitis; Gastroesophageal reflux disease; Neuropathy
Citation
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, v.17, no.3, pp 274 - 278
Pages
5
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
Volume
17
Number
3
Start Page
274
End Page
278
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13339
DOI
10.5056/jnm.2011.17.3.274
ISSN
2093-0879
2093-0887
Abstract
Background/Aims Patients with type II diabetes mellitus (DM) were known to have higher prevalence of gastroesophageal reflux disease (GERD). Recent studies have shown that neuropathy has positive role on the development of GERD in type II DM, although its pathogenesis has not been fully understood yet. The aim of this study was to investigate whether neuropathy really contribute to the development of GERD and typical GERD symptoms in patients with type II DM in Korea. Methods One hundred and nineteen patients with type II DM who had given informed consents were enrolled. All patients underwent electromyography to check the presence of peripheral neuropathy, face-to-face interview to evaluate their typical GERD symptoms and esophagogastroduodenoscopy to look for the presence of erosive esophagitis. Ninety-five patients were finally included for this study and they were divided according to the presence or absence of the peripheral neuropathy. Results The mean age of 95 patients was 59.3 +/- 9.1 years and the mean disease duration of DM was 9.3 +/- 5.9 years. Typical GERD symptoms were similarly found in both groups with and without peripheral neuropathy (23.6% vs 22.8%, P = 0.921). Erosive esophagitis was more prevalent in patients with neuropathy than in those without neuropathy (31.5% vs 10.5%, P = 0.022). Conclusions In patients with type II DM, peripheral neuropathy is an independent risk factor for the erosive esophagitis. However, peripheral neuropathy did not contribute to the presence of the typical GERD symptoms.
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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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