Prospective Evaluation of the Clinical Utility of Interferon-gamma Assay in the Differential Diagnosis of Intestinal Tuberculosis and Crohn's Disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Beom Jin | - |
dc.contributor.author | Choi, Yong Sung | - |
dc.contributor.author | Jang, Byung Ik | - |
dc.contributor.author | Park, Young Sook | - |
dc.contributor.author | Kim, Won Ho | - |
dc.contributor.author | Kim, You Sun | - |
dc.contributor.author | Jung, Sung-Ae | - |
dc.contributor.author | Han, Dong Soo | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Choi, Jai Hyun | - |
dc.contributor.author | Choi, Chang Hwan | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.contributor.author | Cheon, Jae Hee | - |
dc.contributor.author | Ye, Byong Duk | - |
dc.contributor.author | Yang, Suk-Kyun | - |
dc.contributor.author | Kim, Young-Ho | - |
dc.date.available | 2020-11-03T03:44:27Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 1078-0998 | - |
dc.identifier.issn | 1536-4844 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13432 | - |
dc.description.abstract | Background: Distinguishing intestinal tuberculosis (ITB) from Crohn's disease (CD) is challenging. This study prospectively evaluated the clinical utility of the QuantiFERON-TB gold test (QFT) in the differential diagnosis of ITB and CD, and compared it with the clinical utility of the tuberculin skin test (TST). Methods: Patients with suspected ITB or CD on colonoscopic findings were enrolled from 13 hospitals in Korea between June 2007 and November 2008. A QFT and TST were performed. When the initial diagnosis was not confirmed, 2-3 months of empiric antituberculous therapy was administered. Results: In all, 128 patients were analyzed; 64 patients had ITB and 64 patients had CD. The median age of patients with ITB was greater than the patients with CD (47 years versus 31 years, P < 0.001). The positive rate for the QFT and TST (>= 10 mm) in patients with ITB was significantly higher than patients with CD (67% versus 9% and 69% versus 16%, respectively; P < 0.001). The QFT and TST had good agreement (kappa = 0.724, P < 0.001). The diagnostic validity of QFT in ITB had a 67% sensitivity, 90% specificity, 87% positive predictive value, and 73% negative predictive value. There was no difference in these parameters between the QFT and TST. The likelihood ratio for a positive QFT was higher than a positive TST in the diagnosis of ITB (7.1 and 4.4, respectively). Conclusions: The QFT is a limited but useful diagnostic aid in combination with the TST in the diagnosis of ITB. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Prospective Evaluation of the Clinical Utility of Interferon-gamma Assay in the Differential Diagnosis of Intestinal Tuberculosis and Crohn's Disease | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ibd.21490 | - |
dc.identifier.scopusid | 2-s2.0-79955851324 | - |
dc.identifier.wosid | 000290442400028 | - |
dc.identifier.bibliographicCitation | INFLAMMATORY BOWEL DISEASES, v.17, no.6, pp 1308 - 1313 | - |
dc.citation.title | INFLAMMATORY BOWEL DISEASES | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1308 | - |
dc.citation.endPage | 1313 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ACTIVE PULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | CELL-BASED ASSAY | - |
dc.subject.keywordPlus | EXTRAPULMONARY TUBERCULOSIS | - |
dc.subject.keywordPlus | RELEASE ASSAY | - |
dc.subject.keywordPlus | SKIN-TEST | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | BURDEN | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | intestinal tuberculosis | - |
dc.subject.keywordAuthor | Crohn's disease | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordAuthor | interferon-gamma assay | - |
dc.subject.keywordAuthor | tuberculin skin test | - |
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