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Cited 1 time in webofscience Cited 2 time in scopus
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The HBV DNA cutoff value for discriminating patients with HBeAg-negative chronic hepatitis B from inactive carriers

Authors
Kim, Eun SunSeo, Yeon SeokKeum, BoraKim, Ji HoonAn, HyongginYim, Hyung JoonKim, Yong SikLeen, Yoon TaeLee, Hong SikChun, Hoon JaiUm, Soon HoKim, Chang DuckRyu, Ho Sang
Issue Date
May-2011
Publisher
KOWSAR PUBL
Keywords
Hepatitis B virus; Reactivation; Inactive carrier
Citation
HEPATITIS MONTHLY, v.11, no.5, pp.351 - 357
Indexed
SCIE
SCOPUS
Journal Title
HEPATITIS MONTHLY
Volume
11
Number
5
Start Page
351
End Page
357
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13511
ISSN
1735-143X
Abstract
Background: Patients with HBeAg-negative chronic hepatitis B (CHB) has a significantly different prognosis than inactive carriers; there is however, no reliable strategy for accurately differentiating these two disease conditions. Objectives: To determine a strategy for discriminating patients with HBeAg-negative CHB from inactive carriers. Materials and Methods: Consecutive inactive carriers (i.e. HBeAg-negativity, anti-HBe-positivity, normal ALT levels, and HBV DNA <2000 IU/mL) were enrolled. HBV reactivation was defined as the elevation of the HBV DNA level to >= 2000 IU/mL. Patients were classified into true inactive carriers when their HBV DNA levels remained at <2000 IU/mL or false inactive carriers when their HBV DNA levels increased to >= 2000 IU/mL (luring the first year. Results: The Mean +/- SD age of 208 inactive carriers (140 males) was 47.7 +/- 12.6 years. The Mean +/- SD serum ALT and HBV DNA levels were 22.8 +/- 8.6 IU/L and 360 +/- 482 IU/mL, respectively. HBV reactivation developed in 41 (19.7%) patients during the first year. Baseline HBV DNA and ALT levels differed significantly between true inactive and false inactive carriers. The AUROCs of the baseline ALT and HBV DNA levels for predicting a false inactive carrier were 0.609 and 0.831, respectively. HBV reactivation developed more often in patients with a baseline HBV DNA level of >= 200 IU/mL than in those with a baseline HBV DNA level of <200 IU/mL during a Mean +/- SD follow-up of 622 +/- 199 days. Conclusions: The HBV DNA level was useful for discriminating patients with HBeAg-negative CHB from true inactive carriers. The follow-up strategies applied to inactive carriers need to vary with their HBV DNA levels. (C) 2011 Kowsar M.P.Co. All rights reserved.
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5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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