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Cited 17 time in webofscience Cited 17 time in scopus
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Intraindividual Comparison between Gadoxetate-Enhanced Magnetic Resonance Imaging and Dynamic Computed Tomography for Characterizing Focal Hepatic Lesions: A Multicenter, Multireader Studyopen access

Authors
An, ChansikLee, Chang HeeByun, Jae HoLee, Min HeeJeong, Woo KyoungChoi, Sang HyunKim, Do YoungLim, Young-SukKim, Young SeokKim, Ji HoonChoi, Moon SeokKim, Myeong-Jin
Issue Date
Dec-2019
Publisher
KOREAN RADIOLOGICAL SOC
Keywords
Hepatocellular carcinoma; Magnetic resonance imaging; Computed tomography; Contrast media; Data systems; Gadolinium ethoxybenzyl DTPA
Citation
KOREAN JOURNAL OF RADIOLOGY, v.20, no.12, pp.1616 - 1626
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF RADIOLOGY
Volume
20
Number
12
Start Page
1616
End Page
1626
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1360
DOI
10.3348/kjr.2019.0363
ISSN
1229-6929
Abstract
Objective: To compare the diagnostic accuracy of dynamic computed tomography (CT) and gadoxetate-enhanced magnetic resonance imaging (MRI) for characterization of hepatic lesions by using the Liver Imaging Reporting and Data System (LI-RADS) in a multicenter, off-site evaluation. Materials and Methods: In this retrospective multicenter study, we evaluated 231 hepatic lesions (114 hepatocellular carcinomas [HCCs], 58 non-HCC malignancies, and 59 benign lesions) confirmed histologically in 217 patients with chronic liver disease who underwent both gadoxetate-enhanced MRI and dynamic CT at one of five tertiary hospitals. Four radiologists at different institutes independently reviewed all MR images first and the CT images 4 weeks later. They evaluated the major and ancillary imaging features and categorized each hepatic lesion according to the LI-RADS v2014. Diagnostic performance was calculated and compared using generalized estimating equations. Results: MRI showed higher sensitivity and accuracy than CT for diagnosing hepatic malignancies; the pooled sensitivities, specificities, and accuracies for categorizing LR-5/5V/M were 59.0% vs. 72.4% (CT vs. MRI; p < 0.001), 83.5% vs. 83.9% (p = 0.906), and 65.3% vs. 75.3% (p < 0.001), respectively. CT and MRI showed comparable capabilities for differentiating between HCC and other malignancies, with pooled accuracies of 79.9% and 82.4% for categorizing LR-M, respectively (p = 0.139). Conclusion: Gadoxetate-enhanced MRI showed superior accuracy for categorizing LR-5/5V/M in hepatic malignancies in comparison with dynamic CT. Both modalities had comparable accuracies for distinguishing other malignancies from HCC.
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Kim, Ji Hoon
구로병원 (Department of Gastroenterology and Hepatology, Guro Hospital)
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