Intraindividual Comparison between Gadoxetate-Enhanced Magnetic Resonance Imaging and Dynamic Computed Tomography for Characterizing Focal Hepatic Lesions: A Multicenter, Multireader Studyopen access
- An, Chansik; Lee, Chang Hee; Byun, Jae Ho; Lee, Min Hee; Jeong, Woo Kyoung; Choi, Sang Hyun; Kim, Do Young; Lim, Young-Suk; Kim, Young Seok; Kim, Ji Hoon; Choi, Moon Seok; Kim, Myeong-Jin
- Issue Date
- KOREAN RADIOLOGICAL SOC
- Hepatocellular carcinoma; Magnetic resonance imaging; Computed tomography; Contrast media; Data systems; Gadolinium ethoxybenzyl DTPA
- KOREAN JOURNAL OF RADIOLOGY, v.20, no.12, pp.1616 - 1626
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Start Page
- End Page
- Objective: To compare the diagnostic accuracy of dynamic computed tomography (CT) and gadoxetate-enhanced magnetic resonance imaging (MRI) for characterization of hepatic lesions by using the Liver Imaging Reporting and Data System (LI-RADS) in a multicenter, off-site evaluation. Materials and Methods: In this retrospective multicenter study, we evaluated 231 hepatic lesions (114 hepatocellular carcinomas [HCCs], 58 non-HCC malignancies, and 59 benign lesions) confirmed histologically in 217 patients with chronic liver disease who underwent both gadoxetate-enhanced MRI and dynamic CT at one of five tertiary hospitals. Four radiologists at different institutes independently reviewed all MR images first and the CT images 4 weeks later. They evaluated the major and ancillary imaging features and categorized each hepatic lesion according to the LI-RADS v2014. Diagnostic performance was calculated and compared using generalized estimating equations. Results: MRI showed higher sensitivity and accuracy than CT for diagnosing hepatic malignancies; the pooled sensitivities, specificities, and accuracies for categorizing LR-5/5V/M were 59.0% vs. 72.4% (CT vs. MRI; p < 0.001), 83.5% vs. 83.9% (p = 0.906), and 65.3% vs. 75.3% (p < 0.001), respectively. CT and MRI showed comparable capabilities for differentiating between HCC and other malignancies, with pooled accuracies of 79.9% and 82.4% for categorizing LR-M, respectively (p = 0.139). Conclusion: Gadoxetate-enhanced MRI showed superior accuracy for categorizing LR-5/5V/M in hepatic malignancies in comparison with dynamic CT. Both modalities had comparable accuracies for distinguishing other malignancies from HCC.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
- 2. Clinical Science > Department of Radiology > 1. Journal Articles
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