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Cited 27 time in webofscience Cited 27 time in scopus
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Serum aminotransferase levels instead of etiology affects the accuracy of transient elastography in chronic viral hepatitis patients

Authors
Cho, Hye JinSeo, Yeon SeokLee, Kwang GyunHyun, Jong JinAn, HyongginKeum, BoraKim, Ji HoonYim, Hyung JoonJeen, Yoon TaeLee, Hong SikChun, Hoon JaiUm, Soon HoKim, Chang DuckRyu, Ho Sang
Issue Date
Mar-2011
Publisher
WILEY
Keywords
alanine aminotransferase; FibroScan; liver stiffness; necroinflammation
Citation
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.26, no.3, pp.492 - 500
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume
26
Number
3
Start Page
492
End Page
500
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13666
DOI
10.1111/j.1440-1746.2010.06419.x
ISSN
0815-9319
Abstract
Background and Aim: It is still uncertain whether the accuracy of transient elastography (TE) in predicting the fibrosis stage is similar in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The present study was carried out to evaluate whether the underlying cause of chronic viral hepatitis affects the predictive accuracy of TE. Methods: Patients with CHB or CHC who were admitted for a liver biopsy were enrolled. Patients underwent TE and laboratory tests on the same day as the liver biopsy. The predictive accuracy was analyzed by comparing the areas under the receiver-operating characteristic curves (AUCs). Results: Two-hundred and seven patients were enrolled, comprising 121 CHB patients and 86 CHC patients). The patients were aged 44 +/- 14 years, and 121 (58.5%) of them were men. AUCs for predicting significant fibrosis were significantly lower in CHB patients than in CHC patients (P = 0.043). The serum alanine aminotransferase (ALT) level was associated with overestimation and underestimation of the fibrosis stage, while the cause of chronic hepatitis was not. AUCs for predicting significant fibrosis were significantly lower in patients with ALT levels >70 IU/L (AUC, 0.830; 95% CI, 0.742-0.898) than in patients with ALT levels <70 IU/ L (0.944; 0.882-0.979; P = 0.015). Conclusions: Although the predictive accuracy of TE in predicting significant fibrosis differed significantly with the cause of chronic hepatitis, this difference was due to the degree of serum ALT levels rather than to the cause of hepatitis itself. Avoiding performing TE in patients with elevated ALT levels is recommended to guarantee the predictive accuracy of TE.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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