Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy
- Authors
- Lee, Hyo-Suk; Yoo, Byung Chul; Lee, Kwan Sik; Kim, Ju Hyun; Um, Soon-Ho; Ryu, Soo Hyung; Lee, Young-Suk; Kim, Young Soo; Yoo, Kwon; Han, Joon-Yeol; Hwang, Jae Seok; Kim, Tae-Hun; Yang, Jin-Mo; Lee, Heon-Ju; Chon, Chae Yoon; Cho, Mong; Han, Byung Hoon; Hwang, Seong Gyu; Byun, Kwan Soo; Chung, Young-Hwa; Cho, Se-Hyun; Koh, Kwang Cheol; Kim, Byung-Ik; Kim, Haak Cheoul; Paik, Seung Woon; Lee, Myung-Seok; Yoo, Hee-Won; Han, Cheol Ju
- Issue Date
- Mar-2011
- Publisher
- Springer Verlag
- Keywords
- Hepatitis B virus; HBV DNA; ccc-DNA; HBeAg seroconversion; HBsAg loss
- Citation
- Journal of Gastroenterology, v.46, no.3, pp 410 - 414
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Gastroenterology
- Volume
- 46
- Number
- 3
- Start Page
- 410
- End Page
- 414
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13698
- DOI
- 10.1007/s00535-010-0354-x
- ISSN
- 0944-1174
1435-5922
- Abstract
- Background
This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment.
Methods
Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA <4,700 copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA <4,700 copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96 weeks without any treatment for hepatitis B.
Results
Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA <141,500 and <4,700 copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (−0.5 log IU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes.
Conclusions
The clevudine-induced viral response was durable in the majority of patients for 2 years after the withdrawal of treatment.
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- Appears in
Collections - 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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