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Cited 6 time in webofscience Cited 7 time in scopus
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Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy

Authors
Lee, Hyo-SukYoo, Byung ChulLee, Kwan SikKim, Ju HyunUm, Soon-HoRyu, Soo HyungLee, Young-SukKim, Young SooYoo, KwonHan, Joon-YeolHwang, Jae SeokKim, Tae-HunYang, Jin-MoLee, Heon-JuChon, Chae YoonCho, MongHan, Byung HoonHwang, Seong GyuByun, Kwan SooChung, Young-HwaCho, Se-HyunKoh, Kwang CheolKim, Byung-IkKim, Haak CheoulPaik, Seung WoonLee, Myung-SeokYoo, Hee-WonHan, Cheol Ju
Issue Date
Mar-2011
Publisher
Springer Verlag
Keywords
Hepatitis B virus; HBV DNA; ccc-DNA; HBeAg seroconversion; HBsAg loss
Citation
Journal of Gastroenterology, v.46, no.3, pp 410 - 414
Pages
5
Indexed
SCIE
SCOPUS
Journal Title
Journal of Gastroenterology
Volume
46
Number
3
Start Page
410
End Page
414
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13698
DOI
10.1007/s00535-010-0354-x
ISSN
0944-1174
1435-5922
Abstract
Background This study was conducted to evaluate the durability of clevudine-induced viral response after the withdrawal of treatment. Methods Patients who showed a complete response [alanine aminotransferase (ALT) normalization and hepatitis B virus (HBV) DNA <4,700 copies/mL for hepatitis B envelope antigen (HBeAg)-negative patients; ALT normalization, HBV DNA <4,700 copies/mL, and HBeAg seroconversion for HBeAg-positive patients] in the previous clevudine phase III trials were followed for an additional 96 weeks without any treatment for hepatitis B. Results Of the 63 patients in the study cohort, 73% and 35% of the patients had HBV DNA <141,500 and <4,700 copies/mL, respectively, and 75% of the patients had normal ALT at the end of follow-up. HBeAg seroconversion was maintained in 81% of the patients and hepatitis B surface antigen (HBsAg) loss occurred in 3 patients. Continued HBsAg titer decrease (−0.5 log IU/mL) was observed in the sustained viral responders, suggesting the reduction of covalently closed circular DNA in hepatocytes. Conclusions The clevudine-induced viral response was durable in the majority of patients for 2 years after the withdrawal of treatment.
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Byun, Kwan Soo
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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