The Influence of Histologic Inflammation on the Improvement of Liver Stiffness Values Over 1 and 3 Yearsopen access
- Yoo, Jeong-Ju; Seo, Yeon Seok; Kim, Young Seok; Jeong, Soung Won; Jang, Jae Young; Suh, Sang Jun; Yim, Hyung Joon; Suk, Ki Tae; Kim, Dong Joon; Han, Kwang-Hyub; Kim, Seung Up; Lee, Bora; Kim, Sang Gyune; Kwon, Oh Sang; Lee, Sang Heon; Lee, Tae Hee; Jang, Se Young; Jang, Byoung Kuk; Lee, Han Ah; Kim, Byung Seok; Yoon, Ki Tae; Hong, Young Mi; Jang, Eun Sun; Lee, Jeong-Hoon; Kang, Won-suk; Kim, Soon Sun; Cho, Hyo Jung; Lee, Jung Il; Lee, Hyun Woong; Kim, Moon Young; Kang, Seong Hee; Shin, Jung Woo; Kim, Hwi Young; Yoon, Eileen; Heo, Nae-Yun; Lee, Jin Woo; Cho, Seong Beom; Jun, Chung Hwan; Kim, In Hee; Kim, Hyung Joon; Chon, Young Eun; Lee, Byung Seok; Kim, Young Nam; Kim, Sung-Eun; Jeon, Dae Won
- Issue Date
- MDPI AG
- transient elastography; inflammation; liver biopsy
- Journal of Clinical Medicine, v.8, no.12
- Journal Title
- Journal of Clinical Medicine
Transient elastography is now an indispensable tool for estimating liver fibrosis. Although many clinical factors other than fibrosis itself are known to affect liver stiffness (LS) values, it is still not yet clear what factors are related to improving LS values. The aim of this study was to find out how baseline histologic inflammation influences LS values and how much this inflammation affects improvement in LS values over time, regardless of actual fibrosis content.
This retrospective study included 678 consecutive patients who underwent liver biopsy and sequential LS assessment from 2006 to 2015 at six tertiary hospitals in Korea. Linear regression analysis was used to evaluate how improvement of LS value can be associated with other factors besides fibrosis content.
Basal LS values increased with increasing inflammation in the same fibrosis stage. Degree of inflammation influenced the baseline LS value in a proportional manner (beta coefficient (BE), 6.476; 95% confidence interval (CI), 2.24-10.72; p = 0.003). Moreover, histologic inflammation affected the change in LS value significantly. Higher inflammation grade at baseline was a significant predictor for an improvement in LS value, regardless of the fibrosis stage (BE, -8.581; 95% CI, -15.715--1.447; p = 0.019). In a subgroup analysis of patients who received repeated liver biopsies, the results showed a similar tendency.
The LS value is affected by the degree of inflammation even at a low ALT level. Furthermore, baseline histologic inflammation has a significant impact on the improvement of LS values over time. Therefore, baseline inflammation should be taken into consideration when interpreting an improvement in LS value.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.