Detailed Information

Cited 3 time in webofscience Cited 0 time in scopus
Metadata Downloads

The Influence of Histologic Inflammation on the Improvement of Liver Stiffness Values Over 1 and 3 Yearsopen access

Authors
Yoo, Jeong-JuSeo, Yeon SeokKim, Young SeokJeong, Soung WonJang, Jae YoungSuh, Sang JunYim, Hyung JoonSuk, Ki TaeKim, Dong JoonHan, Kwang-HyubKim, Seung UpLee, BoraKim, Sang GyuneKwon, Oh SangLee, Sang HeonLee, Tae HeeJang, Se YoungJang, Byoung KukLee, Han AhKim, Byung SeokYoon, Ki TaeHong, Young MiJang, Eun SunLee, Jeong-HoonKang, Won-sukKim, Soon SunCho, Hyo JungLee, Jung IlLee, Hyun WoongKim, Moon YoungKang, Seong HeeShin, Jung WooKim, Hwi YoungYoon, EileenHeo, Nae-YunLee, Jin WooCho, Seong BeomJun, Chung HwanKim, In HeeKim, Hyung JoonChon, Young EunLee, Byung SeokKim, Young NamKim, Sung-EunJeon, Dae Won
Issue Date
Dec-2019
Publisher
MDPI
Keywords
transient elastography; inflammation; liver biopsy
Citation
JOURNAL OF CLINICAL MEDICINE, v.8, no.12
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF CLINICAL MEDICINE
Volume
8
Number
12
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1381
DOI
10.3390/jcm8122065
ISSN
2077-0383
Abstract
Background: Transient elastography is now an indispensable tool for estimating liver fibrosis. Although many clinical factors other than fibrosis itself are known to affect liver stiffness (LS) values, it is still not yet clear what factors are related to improving LS values. The aim of this study was to find out how baseline histologic inflammation influences LS values and how much this inflammation affects improvement in LS values over time, regardless of actual fibrosis content. Methods: This retrospective study included 678 consecutive patients who underwent liver biopsy and sequential LS assessment from 2006 to 2015 at six tertiary hospitals in Korea. Linear regression analysis was used to evaluate how improvement of LS value can be associated with other factors besides fibrosis content. Results: Basal LS values increased with increasing inflammation in the same fibrosis stage. Degree of inflammation influenced the baseline LS value in a proportional manner (beta coefficient (BE), 6.476; 95% confidence interval (CI), 2.24-10.72; p = 0.003). Moreover, histologic inflammation affected the change in LS value significantly. Higher inflammation grade at baseline was a significant predictor for an improvement in LS value, regardless of the fibrosis stage (BE, -8.581; 95% CI, -15.715--1.447; p = 0.019). In a subgroup analysis of patients who received repeated liver biopsies, the results showed a similar tendency. Conclusions: The LS value is affected by the degree of inflammation even at a low ALT level. Furthermore, baseline histologic inflammation has a significant impact on the improvement of LS values over time. Therefore, baseline inflammation should be taken into consideration when interpreting an improvement in LS value.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yim, Hyung Joon photo

Yim, Hyung Joon
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE