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Cited 7 time in webofscience Cited 6 time in scopus
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Electron microscopic study of intercellular space: Correlation analysis of bronchial asthma and gastroesophageal reflux disease

Authors
Park, SanghoonLee, Eun JooChun, Hoon JaiKeum, BoraSeo, Yeon SeokKim, Yong SikJeen, Yoon-TaeLee, Hong SikUm, Soon HoKim, Chang DuckRyu, Ho SangIn, Kwang HoUhm, Chang-SubLee, Sung Joon
Issue Date
Jan-2011
Publisher
WILEY
Keywords
bronchial asthma; gastroesophageal reflux disease; transmission electron microscopy
Citation
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.26, no.1, pp.104 - 107
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume
26
Number
1
Start Page
104
End Page
107
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13824
DOI
10.1111/j.1440-1746.2010.06410.x
ISSN
0815-9319
Abstract
Background and Aims: Bronchial asthma (BA) is considered an extra-esophageal syndrome of gastroesophageal reflux disease (GERD) with poor pathophysiological background. We analyzed the correlation between GERD and BA, examining esophageal epithelium with transmission electron microscopy (TEM), along with clinical findings. Methods: BA patients of controlled and partly-controlled levels were enrolled in the study. A pulmonary and gastrointestinal (GI) questionnaire was given. Patients with no symptoms joined the control group. Esophageal mucosal tissue was taken by esophagogastroduodenoscopy from both groups and processed for TEM. Intercellular space (IS) was measured with an image analyzing program, 100 times for each patient. Results: The control (n = 20) and BA (n = 20) groups revealed no significant differences in baseline characteristics. All BA patients were using corticosteroid inhalers, with seven patients having a recent history of acute exacerbation. Patients with at least one GI symptom made up 70% (14/20) of the BA group, and heartburn and/or regurgitation were detected in 40% of patients. Endoscopic findings of GERD were mucosal breaks (n = 3). The IS of the control group was 0.389 +/- 0.297 um, while the BA group was 0.806 +/- 0.556 um (P = 0.001). The presence of GERD symptoms (P = 0.306) and a history of recent asthma attacks (P = 0.710) did not show significant differences. Conclusions: The BA group showed a significant difference in the dilatation of IS compared to the control group, suggesting a higher prevalence of GERD in BA patients and a close pathophysiological correlation.
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1. Basic Science > Department of Anatomy > 1. Journal Articles
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles

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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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