Association between the interleukin-18 promoter polymorphism and pulmonary tuberculosis in a Korean population
- Authors
- Lee S.H.; Choi I.-H.; Jeon Y.-K.; Park S.J.; Lee H.-K.; Lee Y.M.; Chang C.L.; Kim Y.S.; Lee M.K.; Park S.K.
- Issue Date
- 2011
- Keywords
- Cavity; Interleukin-18; Single nucleotide polymorphism; Tuberculosis
- Citation
- International Journal of Tuberculosis and Lung Disease, v.15, no.9, pp 1246 - 1251
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- International Journal of Tuberculosis and Lung Disease
- Volume
- 15
- Number
- 9
- Start Page
- 1246
- End Page
- 1251
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14113
- DOI
- 10.5588/ijtld.11.0031
- ISSN
- 1027-3719
1815-7920
- Abstract
- OBJECTIVE: To examine the role of the -667G/T, -618A/C and -148G/C single nucleotide polymorphisms in the promoter region of the human interleukin (IL) 18 gene in the development of pulmonary tuberculosis (PTB), and its radiographic characteristics and severity. DESIGN: Differences in the allele and genotype distributions of the -667G/T, -618A/C, and -148G/C polymorphisms between 251 patients with PTB and 225 healthy controls, between patients with single- and multilobe involvement, and between patients with and without cavities were explored. Serum IL-18 levels were measured using an enzyme-linked immunosorbent assay. RESULTS: The -148G/G genotype was more common in patients with cavities than in those without (82.8% vs. 70.9%, P = 0.04), but an analogous trend was not observed for the -667G/T and -618A/C genotypes. However, there were no signifi cant differences in allele and genotype distributions between patients with PTB and healthy controls, or between patients with singleand multilobe involvement (P > 0.05). Serum IL-18 levels were higher in patients with cavities (P = 0.01) and in patients with the -148G/G genotype (P = 0.02). CONCLUSION: Considering serum IL-18 levels, the -148G/G genotype is associated with a cavitary formation of PTB rather than its development. © 2011 The Union.
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Collections - 2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles
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