Anti-Mullerian hormone and antral follicle count as predictors for embryo/oocyte cryopreservation cycle outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone
- Authors
- Lee S.; Ozkavukcu S.; Heytens E.; Moy F.; Alappat R.M.; Oktay K.
- Issue Date
- 2011
- Keywords
- Anti-Mullerian hormone (AMH); Breast cancer; Cryopreservation; Fertility preservation; Letrozole
- Citation
- Journal of Assisted Reproduction and Genetics, v.28, no.7, pp 651 - 656
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Assisted Reproduction and Genetics
- Volume
- 28
- Number
- 7
- Start Page
- 651
- End Page
- 656
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14134
- DOI
- 10.1007/s10815-011-9567-z
- ISSN
- 1058-0468
1573-7330
- Abstract
- Purpose: To predict embryo/oocyte cryopreservation cycle (ECC) outcomes in breast cancer patients stimulated with letrozole and follicle stimulating hormone for fertility preservation based on observed anti-mullerian hormone (AMH) levels and antral follicle counts (AFC). Methods: The correlation between AMH and AFC and ECC outcomes were analyzed retrospectively on forty one women with breast cancer before adjuvant treatment. Results: AMH and AFC had a stronger correlation with the total number of oocytes and the number of mature oocytes than age, FSH, and inhibin B. Subjects were evaluated by the number of mature oocytes retrieved to create cutoff points of AMH level, which identified 1.2 ng/mL as a potential value. Seven of 18 patients with AMH levels ≤1.2 ng/mL had low response versus none of 23 with >1.2 ng/mL, (p=0.001). Conclusions: AMH is the most reliable serum marker of ECC outcomes, together with AFC as a biophysical marker, in breast cancer patients. Low response is highly likely when the AMH level is ≤1.2 ng/mL. © 2011 Springer Science+Business Media, LLC.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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