Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
- Authors
- Jeong, Soyeon; Jo, Min Jee; Yun, Hye Kyeong; Kim, Dae Yeong; Kim, Bo Ram; Kim, Jung Lim; Park, Seong Hye; Na, Yoo Jin; Jeong, Yoon A.; Kim, Bu Gyeom; Ashktorab, Hassan; Smoot, Duane T.; Heo, Jun Young; Han, Jeongsu; Lee, Sun Il; Kim, Han Do; Kim, Dae Hyun; Oh, Sang Cheul; Lee, Dae-Hee
- Issue Date
- Nov-2019
- Publisher
- Nature Publishing Group
- Citation
- Cell Death and Disease, v.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cell Death and Disease
- Volume
- 10
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1428
- DOI
- 10.1038/s41419-019-2001-7
- ISSN
- 2041-4889
- Abstract
- According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. Here, CBD promoted cell death in gastric cancer. We suggest that CBD induced apoptosis by suppressing X-linked inhibitor apoptosis (XIAP), a member of the IAP protein family. CBD reduced XIAP protein levels while increasing ubiquitination of XIAP. The expression of Smac, a known inhibitor of XIAP, was found to be elevated during CBD treatment. Moreover, CBD treatment increased the interaction between XIAP and Smac by increasing Smac release from mitochondria to the cytosol. CBD has also been shown to affect mitochondrial dysfunction. Taken together, these results suggest that CBD may have potential as a new therapeutic target in gastric cancer.
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- Appears in
Collections - 3. Graduate School > Graduate School > 1. Journal Articles
- 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
- 2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
- 4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles
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