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A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm

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dc.contributor.authorKim, Sang Gyun-
dc.contributor.authorSong, Ho June-
dc.contributor.authorChoi, Il Ju-
dc.contributor.authorCho, Joo Young-
dc.contributor.authorJung, Hwoon-Yong-
dc.contributor.authorKeum, Bora-
dc.contributor.authorCheon, Jae Hee-
dc.contributor.authorLee, Yong Chan-
dc.contributor.authorKim, Jae Gyu-
dc.contributor.authorPark, Sue K.-
dc.contributor.authorPark, Byung Joo-
dc.contributor.authorJung, Hyun Chae-
dc.date.available2020-11-03T04:49:02Z-
dc.date.issued2010-12-
dc.identifier.issn1976-2283-
dc.identifier.issn2005-1212-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14292-
dc.description.abstractBackground/Aims: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. This study involved designing a randomized, double-blinded, placebo-controlled, multicenter trial, performed by the Korean College of Helicobacter and Upper Gastrointestinal Research and the Medical Research Collaboration Center, Seoul National University Hospital. Methods: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection. The enrolled patients are being randomly allocated to the H.-pylori-eradication-plus-proton-pump-inhibitor group or the placebo-plus-proton-pump-inhibitor group based on their histology results and the size of the resected specimen. After random allocation, the iatrogenic ulcer size and stage are evaluated at 4- and 8-week follow-ups (with a window of 7 days). The primary end point is the healing rate of the ulcer by stage, and the secondary end point is the rate of ulcer size reduction, relief rate from ulcer-related symptoms, and adverse-event rates. Results: More than 90% of the target subjects have already been enrolled into the study and are receiving ongoing periodic monitoring by the Medical Research Collaboration Center. Conclusions: Completion of the study should reveal whether H. pylori eradication can facilitate the healing of ulcer after endoscopic resection in Korea. (Gut Liver 2010;4:514-517)-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherEDITORIAL OFFICE GUT & LIVER-
dc.titleA Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasm-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.5009/gnl.2010.4.4.514-
dc.identifier.scopusid2-s2.0-78650653041-
dc.identifier.wosid000285445100010-
dc.identifier.bibliographicCitationGUT AND LIVER, v.4, no.4, pp 514 - 517-
dc.citation.titleGUT AND LIVER-
dc.citation.volume4-
dc.citation.number4-
dc.citation.startPage514-
dc.citation.endPage517-
dc.type.docTypeArticle-
dc.identifier.kciidART001569486-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskciCandi-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusMUCOSAL RESECTION-
dc.subject.keywordPlusOMEPRAZOLE-
dc.subject.keywordPlusFAMOTIDINE-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordAuthorHelicobacter pylori-
dc.subject.keywordAuthorIatrogenic ulcer-
dc.subject.keywordAuthorEndoscopic resection-
dc.subject.keywordAuthorEradication-
dc.subject.keywordAuthorMedical Research Collaboration Center-
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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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