Fanconi's Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient
- Jung, Young Kul; Yeon, Jong Eun; Choi, Jong Hwan; Kim, Chung Ho; Jung, Eun Suk; Kim, Ji Hoon; Park, Jong Jae; Kim, Jae Seon; Bak, Young-Tae; Byun, Kwan Soo
- Issue Date
- 거트앤리버 발행위원회
- Fanconi syndrome; Adefovir; Chronic hepatitis B
- Gut and Liver, v.4, no.3, pp.389 - 393
- Journal Title
- Gut and Liver
- Start Page
- End Page
- Adefovir dipivoxil (ADV) is commonly used as an antiviral agent in the treatment of chronic hepatitis B or human immunodeficiency virus infection. Nephrotoxicity has been shown to occur at daily dosages of 60-120 mg. Fanconi's syndrome is a generalized dysfunction of the renal proximal tubular cells, which is usually accompanied by complications. Here we report a case of Fanconi's syndrome in a chronic hepatitis B patient who had been treated with a prolonged regimen of ADV at 10 mg/day. A 47-year-old man complained of severe back and chest-wall pain. He had chronic hepatitis B and had been treated with ADV at a daily dose of 10 mg for 38 months. He was hospitalized because of severe bone pain, and laboratory and radiologic findings suggested a diagnosis of Fanconi's syndrome with osteomalacia. After discontinuation of the ADV, he recovered and was discharged from hospital. His laboratory findings had normalized within 2 weeks. This case indicates that Fanconi's syndrome can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day. Therefore, patients treated with long-term ADV should be checked regularly for the occurrence of ADV-induced Fanconi's syndrome. (Gut Liver 2010;4:389-393)
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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