Detailed Information

Cited 45 time in webofscience Cited 50 time in scopus
Metadata Downloads

Fanconi's Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient

Authors
Jung, Young KulYeon, Jong EunChoi, Jong HwanKim, Chung HoJung, Eun SukKim, Ji HoonPark, Jong JaeKim, Jae SeonBak, Young-TaeByun, Kwan Soo
Issue Date
Sep-2010
Publisher
거트앤리버 발행위원회
Keywords
Fanconi syndrome; Adefovir; Chronic hepatitis B
Citation
Gut and Liver, v.4, no.3, pp 389 - 393
Pages
5
Indexed
SCIE
SCOPUS
KCICANDI
Journal Title
Gut and Liver
Volume
4
Number
3
Start Page
389
End Page
393
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14485
DOI
10.5009/gnl.2010.4.3.389
ISSN
1976-2283
2005-1212
Abstract
Adefovir dipivoxil (ADV) is commonly used as an antiviral agent in the treatment of chronic hepatitis B or human immunodeficiency virus infection. Nephrotoxicity has been shown to occur at daily dosages of 60-120 mg. Fanconi's syndrome is a generalized dysfunction of the renal proximal tubular cells, which is usually accompanied by complications. Here we report a case of Fanconi's syndrome in a chronic hepatitis B patient who had been treated with a prolonged regimen of ADV at 10 mg/day. A 47-year-old man complained of severe back and chest-wall pain. He had chronic hepatitis B and had been treated with ADV at a daily dose of 10 mg for 38 months. He was hospitalized because of severe bone pain, and laboratory and radiologic findings suggested a diagnosis of Fanconi's syndrome with osteomalacia. After discontinuation of the ADV, he recovered and was discharged from hospital. His laboratory findings had normalized within 2 weeks. This case indicates that Fanconi's syndrome can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day. Therefore, patients treated with long-term ADV should be checked regularly for the occurrence of ADV-induced Fanconi's syndrome. (Gut Liver 2010;4:389-393)
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jung, Young Kul photo

Jung, Young Kul
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE