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Cited 36 time in webofscience Cited 38 time in scopus
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Cutoff points of abdominal obesity indices in screening for non-alcoholic fatty liver disease in Asians

Authors
Yoo, Hye JinPark, Man SikLee, Chang HeeYang, Sae JeongKim, Tae NyunLim, Kang IlKang, Hyun JooSong, WookYeon, Jong EunBaik, Sei HyunChoi, Dong SeopChoi, Kyung Mook
Issue Date
Sep-2010
Publisher
WILEY-BLACKWELL
Keywords
abdominal obesity; non-alcoholic fatty liver disease; receiver operating characteristic curve analysis; visceral fat; waist circumference
Citation
LIVER INTERNATIONAL, v.30, no.8, pp 1189 - 1196
Pages
8
Indexed
SCI
SCIE
SCOPUS
Journal Title
LIVER INTERNATIONAL
Volume
30
Number
8
Start Page
1189
End Page
1196
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14515
DOI
10.1111/j.1478-3231.2010.02300.x
ISSN
1478-3223
1478-3231
Abstract
Background/aims Abdominal obesity is associated with metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Although there have been many studies to determine the optimal cutoff points of waist circumference or visceral fat area in screening for metabolic syndrome, there have been no reports to establish adequate cutoff points of abdominal obesity indices in screening for NAFLD. Therefore, we examined the appropriate cutoff points of abdominal obesity indices associated with NAFLD in Korean men and women using receiver operating characteristic (ROC) curve analysis. Furthermore, we compared the usefulness of various abdominal obesity indices measured using computed tomography (CT), dual-energy X-ray absorptiometry (DXA) and anthropometric parameters for detecting NAFLD. Methods We analysed the baseline data of an ongoing prospective, observational cohort study, including a total of 456 healthy subjects 20-88 years of age. NAFLD was diagnosed by unenhanced CT using the liver attenuation index. Results All ROC curves of waist circumference, waist-to-height ratio, DXA-measured trunk fat mass and CT-measured visceral fat area were significantly above the diagonal line. There were no significant differences in the area under the curve values among these abdominal obesity indices in each gender. The appropriate cutoff point of waist circumference in screening for NAFLD was 89 cm for men and 84 cm for women and the optimal cutoff point of waist-to-height ratio was 0.52 for men and 0.53 for women with very high negative predictive values. Conclusions The simple anthropometric parameters, such as waist circumference and waist-to-height ratio, are as useful as DXA and CT for predicting NAFLD in Korean adults.
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2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Radiology > 1. Journal Articles
2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles

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Choi, Dong Seop
Anam Hospital (Department of Endocrinology and Metabolism, Anam Hospital)
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