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Expression of protein S100A4 is a predictor of recurrence in colorectal canceropen access

Authors
Kwak, Jung MyunLee, Hyun JooKim, Seon HahnKim, Han KyeomMok, Young JaePark, Young TaeChoi, Jong SangMoon, Hong Young
Issue Date
21-Aug-2010
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
S100A4; E-cadherin; p53; Prognostic factor; Colorectal cancer
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.16, no.31, pp.3897 - 3904
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
16
Number
31
Start Page
3897
End Page
3904
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14604
DOI
10.3748/wjg.v16.i31.3897
ISSN
1007-9327
Abstract
AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraffin-embedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraffin array block. Four-mu m sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer. (C) 2010 Baishideng. All rights reserved.
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1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
2. Clinical Science > Department of Foregut Surgery > 1. Journal Articles
2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

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Kim, Han Kyeom
구로병원 (Department of Pathology, Guro Hospital)
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