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Cited 46 time in webofscience Cited 47 time in scopus
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Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B

Authors
Kim, S. U.Seo, Y. S.Cheong, J. Y.Kim, M. Y.Kim, J. K.Um, S. H.Cho, S. W.Paik, S. K.Lee, K. S.Han, K. -H.Ahn, S. H.
Issue Date
Aug-2010
Publisher
WILEY
Citation
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, v.32, no.3, pp.498 - 505
Indexed
SCIE
SCOPUS
Journal Title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume
32
Number
3
Start Page
498
End Page
505
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14614
DOI
10.1111/j.1365-2036.2010.04353.x
ISSN
0269-2813
Abstract
P>Background Interquartile range/median value (IQR/M) of liver stiffness measurement (LSM) is a factor in chronic hepatitis C (CHC) leading to over estimation of fibrosis by Fibroscan. Aim To investigate factors that affect the accuracy of LSM in chronic hepatitis B (CHB). Methods One hundred and ninety-nine patients were enrolled. Only procedures yielding >= 10 valid measurements were considered reliable. Liver fibrosis was evaluated using the Batts and Ludwig system. Liver biopsy (LB) specimens < 15 mm were considered ineligible. Results The mean age (142 men and 57 women) was 40.1 years. A significant discordance (discordance of at least two stages between LB and LSM) was identified in 38 (19.1%) and 47 (23.6%) patients respectively, according to Marcellin et al. and Chan et al.'s cutoff values. In multivariate analyses, BMI and fibrosis stage (F0-2 vs. F3-4) were identified as independent predictors for significant discordance (P = 0.040; hazard ratio [HR], 1.126; 95% confidence interval [CI], 1.005-1.261 and P = 0.036; HR, 0.450; 95% CI, 0.213-0.949 respectively) with Marcellin et al.'s cutoffs, whereas fibrosis stage was the only independent predictor (P = 0.004; HR, 0.300; 95% CI, 0.131-0.685) with Chan's cutoffs. Conclusions Success rate and IQR/M were not predictive factors of the accuracy for diagnosing liver fibrosis by Fibroscan in CHB. Fibrosis stage (F0-2) was the only factor to predict significant discordance between LB and LSM.
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Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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