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Cited 15 time in webofscience Cited 18 time in scopus
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An Electron Microscopic Study-Correlation of Gastroesophageal Reflux Disease and Laryngopharyngeal Reflux

Authors
Park, SanghoonChun, Hoon JaiKeum, BoraUhm, Chang-SubBaek, Seung-KukJung, Kwang-YoonLee, Sung Joon
Issue Date
Jul-2010
Publisher
WILEY
Keywords
Gastroesophageal reflux disease; laryngopharyngeal reflux; transmission electron microscopy
Citation
LARYNGOSCOPE, v.120, no.7, pp.1303 - 1308
Indexed
SCIE
SCOPUS
Journal Title
LARYNGOSCOPE
Volume
120
Number
7
Start Page
1303
End Page
1308
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14721
DOI
10.1002/lary.20918
ISSN
0023-852X
Abstract
Objectives/Hypothesis: Laryngopharyngeal reflux (LPR) originates from regurgitation of gastric contents, a mechanism seemingly identical to gastroesophageal reflux disease (GERD). Some researchers postulate a connection between LPR and GERD, whereas some assert LPR is a disease apart from GERD. We examined symptoms of GERD from LPR patients, and performed gastrointestinal endoscopy and transmission electron microscopy (TEM) to evaluate GERD findings from these patients. Study Design: Prospective study at an academic tertiary care center. Methods: Control subjects had no symptoms or signs of LPR/GERD. LPR was diagnosed with a Reflux Symptom Index >13 and Reflux Finding Score >7, and were questioned for GERD-related symptoms and examined with esophagogastroduodenoscopy, then allocated into either an LPR without GERD or LPR with GERD group. Esophageal tissues were obtained from the squamocolumnar junction and managed for TEM, and the intercellular space (IS) was measured to find dilatation, a characteristic GERD finding. Results: About 30% (8/26) of LPR patients showed GERD-related symptoms, connecting LPR with the GERD group. Most of the LPR patients showed grossly normal endoscopic findings. On TEM, IS of control group (n = 15) was measured as 0.35 +/- 0.27 mu m, whereas the LPR without GERD group (n = 18) and LPR with GERD group (n = 8) revealed a dilated IS of 0.61 +/- 0.47 mu m and 0.95 +/- 0.44 mu m, respectively. This difference was statistically significant compared to the control group (P < .05). Conclusions: The mean IS of LPR was significantly increased, suggesting common pathogenesis between LPR and GERD.
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2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles
1. Basic Science > Department of Anatomy > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Chun, Hoon Jai
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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