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Cited 28 time in webofscience Cited 32 time in scopus
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Visfatin is upregulated in type-2 diabetic rats and targets renal cells

Authors
Kang, Young SunSong, Hye KyoungLee, Mi HwaKo, Gang JeeHan, Jee YoungHan, Sang YoubHan, Kum HyunKim, Hyoung KyuCha, Dae Ryong
Issue Date
Jul-2010
Publisher
ELSEVIER SCIENCE INC
Keywords
diabetic nephropathy; glucose transporter-1; type-2 diabetic rats; visfatin
Citation
KIDNEY INTERNATIONAL, v.78, no.2, pp.170 - 181
Indexed
SCIE
SCOPUS
Journal Title
KIDNEY INTERNATIONAL
Volume
78
Number
2
Start Page
170
End Page
181
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14724
DOI
10.1038/ki.2010.98
ISSN
0085-2538
Abstract
Visfatin (also known as pre-B cell colony-enhancing factor) is a newly discovered adipocytokine that is preferentially produced by visceral fat and regulated by cytokines promoting insulin resistance. Here we determined its renal synthesis and physiology in a genetic model of type 2 diabetes in rats. These rats had higher levels of visfatin synthesis in both glomeruli and tubulointerstitium compared to control rats. Plasma visfatin levels were significantly increased in the early stages of diabetic nephropathy and positively correlated with body weight, fasting plasma glucose, and microalbuminuria. Interestingly, visfatin synthesis was found to occur in podocytes and proximal tubular cells, as well as in adipocytes in vitro. Further, in both renal cells, visfatin synthesis was significantly increased by high glucose in the media but not by angiotensin II. Additionally, visfatin treatment induced rapid uptake of glucose and was associated with increased translocation of GLUT-1 to the cellular membrane of both renal cell types. Furthermore, visfatin induced tyrosine phosphorylation of the insulin receptor, activated downstream insulin signaling pathways such as Erk-1, Akt, and p38 MAPK, and markedly increased the levels of TGF beta 1, PAI-1, type I collagen, and MCP-1 in both renal cells. Thus, our results suggest that visfatin is produced by renal cells and has an important paracrine role in the pathogenesis of diabetic nephropathy. Kidney International (2010) 78, 170-181; doi:10.1038/ki.2010.98; published online 14 April 2010
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Cha, Dae Ryong
Ansan Hospital (Department of Nephrology and Hypertension, Ansan Hospital)
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